Multi-valued logical models can be used to describe biological networks on a high level of abstraction based on the network structure and logical parameters capturing regulatory effects. Interestingly, the dynamics of two distinct models need not necessarily be different, which might hint at either only non-functional characteristics distinguishing the models or at different possible implementations for the same behaviour.Here, we study the conditions allowing for such effects by analysing classes of dynamically equivalent models and both structurally maximal and minimal representatives of such classes. Finally, we present an efficient algorithm that constructs a minimal representative of the respective class of a given multi-valued model.
Logical modeling of biological regulatory networks gives rise to a representation of the system's dynamics as a so-called state transition graph. Analysis of such a graph in its entirety allows for a comprehensive understanding of the functionalities and behavior of the modeled system. However, the size of the vertex set of the graph is exponential in the number of the network components making analysis costly, motivating development of reduction methods. In this paper, we present results allowing for a complete description of an asynchronous state transition graph of a Thomas network solely based on the analysis of the subgraph induced by certain extremal states. Utilizing this notion, we compare the behavior of a simple multivalued network and a corresponding Boolean network and analyze the conservation of dynamical properties between them. Understanding the relation between such coarser and finer models is a necessary step toward meaningful network reduction as well as model refinement methods.
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