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Targeted drug delivery systems gave newer dimensions for safer and more effective use of therapeutic drugs, thus helping in circumventing the issues of toxicity and unintended drug accumulation. These ongoing developments in delivery systems can, in turn, bring back drugs that suffered various limitations, Ellipticine (EPT) being a candidate. EPT derivatives witnessed entry into clinical settings but failed to survive in clinics citing various toxic side effects. A large body of preclinical data deliberates the potency of drug delivery systems in increasing the efficiency of EPT/derivatives while decreasing their toxic side effects. Recent developments in drug delivery systems provide a platform to explore EPT and its derivatives as good clinical candidates in treating tumors. The present review deals with delivery mechanisms of EPT/EPT derivatives as antitumor drugs, in vitro and in vivo, and evaluates the suitability of EPT-carriers in clinical settings.

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A field trial was conducted to study the dissipation of neonicotinoid insecticides, imidacloprid and acetamiprid, on chilli fruits for the estimation of its half-life and waiting period. The samples of chilli fruits drawn at 0, 1, 3, 5, 7, 15, 21 days after spraying were quantified on gas liquid chromatography equipped with Ni 63 electron capture detector for acetamiprid and high performance liquid chromatography for imidacloprid. The residues of imidacloprid persisted up to seven days, whereas the acetamiprid persisted up to fifteen days of spraying. From the dissipation data, the half-life values of acetamiprid and imidacloprid were 2.27 and 2.08 days, respectively. A waiting period of 7.18 and 11.26 days were calculated for acetamiprid and imidacloprid in chilli.

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