The MCDM problem is very important and often encountered in life and in engineering as it is used to determine the best solution among various possible alternatives. In this paper, the results of the MCDM problem in the dressing process for internal grinding are presented. To perform this work, an experiment with six input parameters, including the depth and the time of fine dressing, the depth and the time of coarse dressing, non-feeding dressing, and dressing feed rate, was conducted. The experiment was designed according to the Taguchi method with the use of L16 orthogonal arrays. In addition, TOPSIS, MARCOS, EAMR and MAIRCA methods were selected for the MCDM to obtain the minimum SR and the maximum MRR simultaneously. In addition, the weight determination for criteria was implemented by MEREC and entropy methods. From the results, the best solution to the multi-criteria problem for the dressing process in internal grinding has been proposed.
Alcohol is a widely used and abused substance. A major unresolved issue in the alcohol research field is determining which of the many alcohol target proteins identified to date is responsible for shaping each specific alcohol-related behavior. The large-conductance, calcium- and voltage-activated potassium channel (BK channel) is a conserved target of ethanol. Genetic manipulation of the highly conserved BK channel influences alcohol-related behaviors across phylogenetically diverse species that include worm, fly, mouse, and man. A pharmacological tool that prevents alcohol's action at a single target, like the BK channel, would complement genetic approaches in the quest to define the behavioral consequences of alcohol at each target. To identify agents that specifically modulate the action of ethanol at the BK channel, we executed a high-throughput phagemid-display screen in combination with a behavioral genetics assay. This screen selected a novel nonapeptide, LS10, which moderated acute ethanol intoxication in a BK channel-humanized strain without altering basal behavior. LS10's action in vivo was dependent upon BK channel functional activity. Single-channel electrophysiological recordings in vitro showed that preincubation with a submicromolar concentration of LS10 restricted ethanol-induced changes in human BK channel gating. In contrast, no substantial changes in basal human BK channel function were observed after LS10 application. The results obtained with the LS10 peptide provide proof-of-concept evidence that a combined phagemid-display/behavioral genetics screening approach can provide novel tools for understanding the action of alcohol at the BK channel and how this, in turn, exerts influence over central nervous system function.
The blasting technique has been broadly utilized to prepare new surfaces for painting, engraving, etc., in industry. In fact, the minimization of the cleaning cost system is essential. However, the knowledge of this technique in terms of optimization has been poor so far. The aim of this study is to find the optimum replaced boron carbide nozzle diameter for the abrasive blasting system. The basis of the study is to find the replaced nozzle diameter to minimize the cost of the blasting system. Seven main parameters are adopted for examining their influences on the response and the optimum replaced nozzle diameter. The design of experiment (DOE) technique is utilized by using Minitab@19. The results reveal that the initial nozzle diameter has the strongest impact on the optimum replaced nozzle diameter. Furthermore, the proposed regression model has been found to be entirely insistent to the experiments. The utilization of this model can provide an effective way to simplify the calculation of the optimum initial nozzle diameter for boron carbide.
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