There has been no systematic evaluation of Viet Nam's A6 mortality reporting system. An evaluation was undertaken in 3 provinces in Viet Nam. Deaths identified in the A6 system were compared with deaths identified by an independent consensus panel to determine the percentage completeness of the A6 system. Verbal autopsies (VAs) were conducted for all identified deaths from the consensus panels, and the sensitivity and positive predictive value of the A6 system was assessed. The sensitivity of the A6 system varied depending on the cause of death, with the sensitivity of the system being excellent for injury (sensitivity = 75.4%), cancer (sensitivity = 66.9%), and circulatory diseases (sensitivity = 63.1%). The A6 mortality reporting system performs well in relation to its completeness and classification of 3 leading causes of death—namely, circulatory disease, cancer, and injury. With further enhancements and ongoing support from government and donor agencies, the A6 system will be a valuable resource.
A bioassay-guided phytochemical fractionation of the methanol extract of the Morus alba root barks led to the isolation of two chalcone-derived Diels-Alder adducts (1 and 2). Their structures were elucidated as kuwanon J 2,4,10″-trimethyl ether (1) and kuwanon R (2) by means of spectroscopic methods. Both compounds strongly inhibited nuclear transcription factor.κB activity with the IC₅₀ values of 4.65 and 7.38 μM, respectively.
The toxicity and antitumour effect of the ethanol extract of Selaginella tamariscina (STE), a plant widely used in folk medicine, were examined in a mice model. In the single-dose acute toxicity test, an oral administration of 10,000 mg kg(-1) STE did not cause any lethality. The sub-acute toxicity study showed that the treatment by 250, 1000 and 3000 mg kg(-1 )day(-1) for 30 continuous days did neither alter the body weights nor the haematological parameters in BALB/c mice. The anticancer effect of STE was evaluated in BALB/c mice inoculated with Lewis lung carcinoma cells. Oral administration of STE could not prevent the tumour formation but provided strong inhibition of tumour growth.
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