Schizophrenia is a life altering disease with a complex etiology and pathophysiology, and although antipsychotics are valuable in treating the disorder, certain symptoms and/or sufferers remain resistant to treatment. Our poor understanding of the underlying neuropathological mechanisms of schizophrenia hinders the discovery and development of improved pharmacological treatment, so that filling these gaps is of utmost importance for an improved outcome. A vast amount of clinical data has strongly implicated the role of inflammation and oxidative insults in the pathophysiology of schizophrenia. Preclinical studies using animal models are fundamental in our understanding of disease development and pathology as well as the discovery and development of novel treatment options. In particular, social isolation rearing (SIR) and pre- or postnatal inflammation (PPNI) have shown great promise in mimicking the biobehavioral manifestations of schizophrenia. Furthermore, the "dual-hit" hypothesis of schizophrenia states that a first adverse event such as genetic predisposition or a prenatal insult renders an individual susceptible to develop the disease, while a second insult (e.g., postnatal inflammation, environmental adversity, or drug abuse) may be necessary to precipitate the full-blown syndrome. Animal models that emphasize the "dual-hit" hypothesis therefore provide valuable insight into understanding disease progression. In this Review, we will discuss SIR, PPNI, as well as possible "dual-hit" animal models within the context of the redox-immune-inflammatory hypothesis of schizophrenia, correlating such changes with the recognized monoamine and behavioral alterations of schizophrenia. Finally, based on these models, we will review new therapeutic options, especially those targeting immune-inflammatory and redox pathways.

Prenatal LPS, LPS + postnatal MA challenge during adolescence, and to a lesser extent MA alone, promotes schizophrenia-like bio-behavioural changes later in life that are reversed by NAC, emphasizing therapeutic potential for schizophrenia and MA-associated psychosis. The nature and timing of the dual-hit are critical.

Teaching journalism prior to and after the demise of Christian higher education at Potchefstroom

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The nature of HIV/Aids media coverage has been widely criticised, mainly by interest groups. Thishas resulted in constructive, though somewhat fragmented, guidelines on ethically acceptable,accountable HIV/Aids reporting. In this article the analysed and systematically summarisedguidelines (Swanepoel, 2005:77-137) are used to evaluate HIV/Aids reporting in three SouthAfrican Sunday papers. It was found that these newspapers partially meet the interest groupcriteria. They raise awareness satisfactorily, but agenda setting could be improved. Although thereis comprehensive coverage of HIV/Aids issues, critical, in-depth reporting is lacking. Furthermore,there is an exaggerated focus on HIV/Aids politics, and too little on relevant scientific and socialissues. A lack of alternative angles and a tendency towards sensationalism are noticeable. Thethree papers often emphasise the “victim image”, and fail to use HIV/Aids-sensitive languageconsistently. In respect of accuracy, there are deficiencies in the use of news source

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The article discusses the coverage of politics in South African women's magazine Fair Lady in selected years from democratisation in 1994 to ten years later in 2004. In a democracy, the media has the explicit duty to inform society. Within this context three questions are asked: (1) Which political themes are covered? (2) In what genres do the political items feature? (3) In what ways does the magazine focus the reader's attention on political items? These aspects were selected to provide a clear view of the extent and manner in which Fair Lady presents politics in its content. This study was done by means of a qualitative content analysis. By focusing on these issues and by drawing on the functions of the media; the agenda setting theory; the schema theory and the on-line evaluation theory, it is argued that the magazine deems politics as important and incorporates it on its agenda to provide readers with necessary political information which they might not otherwise attain. Fair Lady overcomes the fact that politics does not traditionally feature in women's magazines by taking care in attracting and keeping readers' attention to political items. The publication (especially in 2004) can be held up as an example to other women's magazines trying to fulfil their function as a medium to educate and inform readers whilst at the same time not alienating the entertainmentseekers.