Introdução: O subtipo triplo negativo é conhecido por apresentar um comportamento agressivo e se refere a tumores que não expressam receptores de estrogênio, progesterona e HER2. Metodologia: É um estudo epidemiológico observacional, transversal e retrospectivo que abrange o período de 2010 a 2014. Foram analisados 1208 prontuários de pacientes com câncer de mama primário dispensados pelo Laboratório de Patologia da FCECON. A tabulação dos dados foi feita através do Microsoft® Office Excel 2013 e a análise foi conduzida através do software estatístico R versão 3.5.3 (R Core Team). Objetivos: Avaliar a frequência do subtipo triplo negativo e correlacionar com a idade, tipo histológico, estadiamento e tratamento inicial das pacientes com câncer de mama da FCECON-AM. Resultados: Dos prontuários analisados, 147 (12,2%) das mulheres possuiam subtipo triplo negativo, a idade das pacientes variou de 33 a 85 anos, com idade média de 53,6 ± 11,9 anos, mediana igual a 52 e a maioria das pacientes eram procedentes de Manaus (60%). No que concerne ao tipo histológico, o ductal foi o mais frequente(86,4%); em relação ao estadiamento clínico, os estádios IIA e IIIB foram os mais frequentes, com 25,9% e 27,2% respectivamente; sobre a abordagem terapêutica inicial, a mastectomia esteve presente em 57,8% dos casos. Conclusão: Conclui-se que a faixa etária de 41 a 48 anos foi a que mais apresentou o subtipo triplo negativo (23,8%). Além disso, o tratamento inicial mais frequente foi a mastectomia.
SUMMARY OBJECTIVE: This study aimed to assess the sociodemographic and clinical profile of women deprived of their liberty and to identify the prevalence of sexually transmitted diseases and human papillomavirus through self-sampling samples. METHODS: This is an epidemiological, cross-sectional, observational, and descriptive study of the prevalence and correlation of the diagnosis of human papillomavirus infection in 268 encarcered women in Amazonas submitted to self-sampling from June 2019 to September 2020 using the genotyping analysis. Patients with positive and inconclusive results were evaluated by commercialized PCR to detect pathogens causing sexually transmitted diseases. The sample size used was based on a convenience sample. RESULTS: In 268 women, human papillomavirus DNA was detected in 87 (32.5%) of them. Sexually transmitted diseases were detected in 30 (34.48%) of the 87 women with a positive or inconclusive result for human papillomavirus. Women with more than three pregnancies had a higher risk of human papillomavirus detection (p=0.004). CONCLUSION: The prevalence of human papillomavirus and other sexually transmitted diseases in encarcered women in Amazonas is 32.5 and 34.48%, respectively. Most women were single (60.4%) and reported having had more than 15 partners (90.8%).
Objective: To demonstrate the time between the diagnosis of the disease, the result of the immunohistochemical panel and the beginning of specialized treatment in patients diagnosed with breast cancer seen at the Foundation Center of Oncology of the State of Amazonas, from June to November 2018 and in the same period of 2019. Methods: The study was part retrospective, based on data from medical records, and part prospective, based on data from patients, and we evaluated the time between diagnosis from the immunohistochemical panel and the beginning of specialized treatment in breast cancer patients. Results: 170 patients diagnosed with breast cancer were included, 71 from June to November 2018 and 99 breast cancer patients seen from June to November 2019. The median time between diagnosis and immunohistochemistry results of all patients was 36 days, and comparing the two groups of patients, it was observed that for half of the 2018 patients, the time was less than 105 days, while for half of the 2019 patients, it was less than 27 days. If the times between the result of the immunohistochemical panel and the start of personalized treatment in both groups were compared, it was seen that the median time until the start of treatment was longer for patients in 2018, 94.5 days versus 79 days for patients in 2019. Conclusion: There was a decrease in the time between the diagnosis and the result of the molecular panel in 2019 compared to 2018. Achieving this result more quickly provided the choice of personalized treatment for each patient, having an important impact on survival in that population.
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