Waste generation and waste management are critical environmental issues faced by countries all over the world. Furthermore, there are greater environmental, economic, and social demands on firms to reduce the environmental impacts due to environmental problems brought about by their operating activities. There is a current debate as to the financial implications of waste management expenditure on waste reduction targets. This study examines the relationship between waste management expenditure on waste reduction targets, and the impact of waste reduction targets on firms' profitability. This study used the quantitative method that utilizes the multiple regressions method to analyses data from selected South African Johannesburg Stock Exchange's (JSE) Socially Responsible Index (SRI) listed manufacturing and mining firms for ten years (2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016). The study tests if there is a relationship between waste management expenditure and waste reduction targets, as well as the impact of waste reduction targets on firms' profitability. Results show that waste reduction targets have a positive, but insignificant, correlation on the profitability of firms, and also indicate that there is a relationship between waste management expenditure and waste reduction targets. The study recommends that firms should focus more on minimizing waste generation to reduce costs.