Since we demonstrated beneficial effects on spinal cord IR injury, we think that both HBO and IL, either alone or in combination, may be reasonable in the treatment of IR injury. Furthermore, there did not appear to be synergistic effects with combined treatment. More research is needed for practical application in humans, following thoracoabdominal aortic surgery.
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Hybrid procedures could be performed safely with lower complication and higher success rates in the same session via antegrade route and zone 0 graft deployment for high-risk cases with isolated or nonisolated aortic arch aneurysms.
Objective. The objective of this study was to examine the effects of iloprost and N-acetylcysteine (NAC) on ischemia-reperfusion (IR) injuries to the gastrocnemius muscle, following the occlusion-reperfusion period in the abdominal aorta of rats. Materials and Methods. Forty male Sprague-Dawley rats were randomly divided into four equal groups. Group 1: control group. Group 2 (IR): aorta was occluded. The clamp was removed after 1 hour of ischemia. Blood samples and muscle tissue specimens were collected following a 2-hour reperfusion period. Group 3 (IR + iloprost): during a 1-hour ischemia period, iloprost infusion was initiated from the jugular catheter. During a 2-hour reperfusion period, the iloprost infusion continued. Group 4 (IR + NAC): similar to the iloprost group. Findings. The mean total oxidant status, CK, and LDH levels were highest in Group 2 and lowest in Group 1. The levels of these parameters in Group 3 and Group 4 were lower compared to Group 2 and higher compared to Group 1 (P < 0.05). The histopathological examination showed that Group 3 and Group 4, compared to Group 2, had preserved appearance with respect to hemorrhage, necrosis, loss of nuclei, infiltration, and similar parameters. Conclusion. Iloprost and NAC are effective against ischemia-reperfusion injury and decrease ischemia-related tissue injury.
Amaç: Bu çalışmada, abdominal aort anevrizmasının (AAA) tamirinde sentetik greft ile konvansiyonel yaklaşım ve endovasküler stent greft (EVAR) yaklaşımının sonuçları karşılaştırıldı. Ça lış ma pla nı: Ağustos 2003 -Ekim 2010 tarihleri arasında kliniğimizde AAA nedeniyle elektif şartlarda konvansiyonel cerrahi tedavi veya EVAR uygulanmış 150 hasta (142 erkek, 8 kadın; yaş 67.43 yıl; dağılım 36-86 yıl) retrospektif olarak incelendi. Hastaların erken dönem mortalite oranları, ameliyat süresi, kan kaybı, transfüzyon gereksinimi, mekanik ventilasyon süresi, yoğun bakımda ve hastanede yatış süreleri kaydedildi. Bul gu lar: Mortalite oranı EVAR uygulanan hastalarda %1.9 iken, konvansiyonel cerrahi uygulanan hastalarda %9.3 olarak saptandı (p<0.05). Ortalama kan transfüzyonu EVAR grubunda 2.7±3.0 ünite iken, konvansiyonel cerrahi uygulanan hasta grubunda 5.6±3.9 ünite idi (p<0.05). Ortalama ameliyat süresi, ortalama mekanik ventilasyon süresi, ortalama yoğun bakımda kalma süresi, ortalama hastanede yatış süresi EVAR uygulanan hastalarda, konvansiyonel cerrahi uygulanan hastalara kıyasla, istatistiksel olarak anlamlı düşüktü. So nuç: EVAR yaşlı ve ameliyat riskinin yüksek olduğu veya greft teknolojilerindeki gelişmeler sonucunda anatomik olarak uygun olan hastalarda düşük mortalite ve morbidite oranları ile uygulanan etkili bir alternatif tedavi yöntemi olabilir.Anah tar söz cük ler: Abdominal aort anevrizması; endovasküler tedavi; konvansiyonel cerrahi tedavi.
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