This report describes the isolation and characterization of kalanchosine dimalate (KMC), an anti-inflammatory salt
from the fresh juice of the aerial parts of Kalanchoe
brasiliensis. KMC comprises the new metabolite kalanchosine (1)
and malic acid (2) in a 1:2 stoichiometric ratio. Kalanchosine (1), 3,6-diamino-4,5-dihydroxyoctanedioic acid, is the
first naturally occurring dimeric bis(γ-hydroxy-β-amino acid) and is at least partially responsible for the anti-inflammatory
properties of K. brasiliensis.
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