PurposeThe aim of this study is to investigate the role of health-related quality-of-life (QoL) data in relative effectiveness assessments (REAs) of new anti-cancer drugs across European jurisdictions, during health technology assessment procedures.MethodsComparative analysis of guidelines and publicly available REAs in six European jurisdictions of anti-cancer drugs approved by EMA between 2011 and 2013.ResultsFourteen anti-cancer drugs were included, adding up to 79 REAs. Whilst all guidelines state that QoL is a relevant endpoint to determine the relative effectiveness of new cancer drugs, QoL data were included in only 54% of the 79 reports and their impact on the recommendations was limited.ConclusionsWhilst national guidelines recognize the relevance of QoL to determine the relative effectiveness of new anti-cancer drugs, this is not well-reflected in current assessments. Developing and implementing into REAs specific evidence requirements for QoL data would improve the use of this patient-centred outcome in future reimbursement and pricing decisions.Electronic supplementary materialThe online version of this article (doi:10.1007/s11136-017-1574-9) contains supplementary material, which is available to authorized users.
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:To assess the effects of unbranded advertising of prescription medicines, conducted by or on behalf of pharmaceutical companies, on consumers' attitudes, knowledge, behaviour, health services use, health outcomes and costs.
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