arms, 27% of patients had IL-6 levels ≥3 pg/mL and 13% had CRP levels ≥5 mg/L, at the end of the MONET trial. The risk of elevations in IL-6 was greater for patients with HCV coinfection. Therefore, new analyses correlating IL-6 and CRP levels with clinical disease progression or cardiovascular risk need to control for coinfection with HCV.
FundingThe MONET trial was funded by Janssen.
Transparency declarationsJ. A. has received payments from Janssen for speaker engagements and advisory boards. A. H. has received consultancy payments from Janssen. N. X., Y. van D. and C. M. are employees of Janssen.
Pyogenic liver abscesses are uncommon in clinical practice and are usually polymicrobial in nature, with members of the Enterobacteriacae family often implicated. This report describes the use of tigecycline to treat a liver abscess caused by methicillin-resistant Staphylococcus aureus, which was refractory to therapy with standard antimicrobials.
A case of septic arthritis post anterior cruciate ligament reconstruction secondary to Clostridium sporogenes is described in a 19-year-old man. C sporogenes is a rare clinical pathogen and this is believed to be the first case of septic arthritis due to the organism. The patient responded to arthroscopic washout, synovectomy and combination antibiotic therapy. A review of the literature is also presented.
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