Objective: To assess the association between atopic dermatitis (AD) and ascariasis in 2 to 10-aged children from the neighborhood Pedregal, in the city of Campina Grande, Brazil, an area of low socioeconomic index. Methods:Cross-sectional study conducted with the use of the standard questionnaire from the International Study of Asthma and Allergies in Childhood (ISAAC) and stool parasitological exam for Ascaris lumbricoides. The dependent variable was AD diagnosis: absent, mild, and severe. Multivariate logistic regression and descriptive analysis of the variable were used. Associations were estimated using relative risk (RR) and odds ratio (OR). The statistical inference was based on 95% confidence intervals (95%CI). Results:We assessed 1,195 children, 612 (51.2%) female. The AD prevalence was 24.6%, and ascariasis prevalence was 26.1%. In the mild AD group of children, 44 (36.7%) were infected by A. lumbricoides, while in the severe AD group, 40 (22.9%) had the same geohelminthosis (p = 0.01). Comparing negative cases of AD between mild and severe forms, the infection with A. lumbricoides increased the frequency of mild AD (RR = 1.7; p = 0.009), but not the severe form (RR = 0.86; p = 0.46). Evaluating only the positive cases of dermatitis, 120 mild AD (40.8%) and 176 with severe AD (58.2%), it can be said that the exposure to the parasite decreased the frequency of the severe form of dermatitis (RR = 1.46; p = 0.016). Conclusion:There is a high prevalence of AD and of ascariasis in the population studied. The severe AD is related to lower parasitemia of A. lumbricoides. J Pediatr (Rio J). 2010;86(1):53-58: Atopic dermatitis, ascariasis, prevalence, children. ResumoObjetivo: Avaliar a associação entre dermatite atópica (DA) e ascaridíase em crianças de 2 a 10 anos do bairro do Pedregal, Campina Grande (PB), área de baixos indicadores socioeconômicos.Métodos: Trata-se de estudo transversal a partir da aplicação do questionário padrão do International Study of Asthma and Allergies in Chlidhood (ISAAC) e exame parasitológico de fezes para Ascaris lumbricoides. A variável dependente foi o diagnóstico de DA ausente, DA leve e DA grave. Efetuou-se análise de regressão logística multivariada, bem como análise descritiva das variáveis do estudo. As associações foram estimadas por meio de risco relativo (RR) e razão de chances (odds ratio, OR). A inferência estatística foi baseada em intervalos de confiança de 95% (IC95%). Resultados:Foram avaliadas 1.195 crianças, sendo 51,2% (n = 612) do sexo feminino. A prevalência de DA foi de 24,6%, e a de ascaridíase, de 26,1%. Das crianças com DA leve, 44 (36,7%) eram parasitadas pelo A. lumbricoides, enquanto que 40 (22,9%), com DA grave, apresentavam a mesma geo-helmintose (p = 0,01). Comparando-se os casos negativos para DA com os casos leves e graves, constatou-se que a presença de ascaridíase aumentou a ocorrência de dermatite leve (RR = 1,7; p = 0,009), mas não de DA grave (RR = 0,86; p = 0,46). Avaliando-se apenas os casos positivos de dermatite, DA leve (n = 120;...
Introduction: Ascaris lumbricoides-infected patients present lower prevalence of severe atopic dermatitis. Methods: Peripheral blood of infected children with atopic dermatitis was assessed by flow cytometry of the frequency of Th1 and Th2 cells through the expression of CXCR3 and CCR4 chemokine receptors, respectively. Results: Helminth-free patients with atopic dermatitis presented a high frequency of CCR4+Th2 cells. Parasitized patients with atopic dermatitis showed a lower frequency of CXCR3+Th1 cells compared to infected individuals only. Conclusions: Ascariasis modifies the blood traffic of Th2 cells in atopic dermatitis patients, while the allergic disease down-regulates the traffic of Th1 cells in parasitized patients.
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