Recently, prediction of lncRNA-disease associations has attracted more and more attentions. Various computational models have been proposed; however, there is still room to improve the prediction accuracy. In this paper, we propose a kernel fusion method with different types of similarities for the lncRNAs and diseases. The expression similarity and cosine similarity are used for lncRNAs, and the semantic similarity and cosine similarity are used for the diseases. To eliminate the noise effect, a neighbor constraint is enforced to refine all the similarity matrices before fusion. Experimental results show that the proposed similarity kernel fusion (SKF)-LDA method has the superiority performance in terms of AUC values and other measurements. In the schemes of LOOCV and 5-fold CV, AUC values of SKF-LDA achieve 0.9049 and 0.8743±0.0050 respectively. In addition, the conducted case studies of three diseases (hepatocellular carcinoma, lung cancer, and prostate cancer) show that SKF-LDA can predict related lncRNAs accurately.
We achieve laser frequency stabilization by a simple technique based on sub-Doppler dichroic atomic vapor laser lock (DAVLL) in atomic cesium. The technique that combines saturated-absorption spectroscopy and Zeeman splitting of hyperfine structures allows us to obtain a modulation-free dispersion-like error signal for frequency stabilization. For the error signal, the dependence of peak-to-peak amplitude and the slope at the zero-crossing point on the magnetic field is studied by simulation and experiment. Based on the result, we obtain an available sub-Doppler DAVLL error signal with high sensitivity to the frequency drift by selecting an appropriate strength of the magnetic field. Ultimately, the fluctuation of the locked laser frequency is confined to below 0.5 MHz in a long term, exhibiting efficient suppression of frequency noise.
We theoretically and experimentally investigate hyperfine dipole-dipole broadening in the selective reflection (SR) spectroscopy at the gas-solid interface with the atomic density of 10 14 -10 15 cm −3 . The two-level SR theory considering pump beam and dipole-dipole interaction between excited-state atom and ground-state atom is presented. The numerical simulation of the SR spectrum is in agreement with experimental results. The reduction of spectral width is observed by introducing a pump beam which is an effective technique to improve the resolution of spectroscopy. We analyze the dependence of dipole-dipole broadening on atomic density and pump beam power. This study is helpful for the description of the SR spectroscopy at the gas-solid interface where the Doppler broadening is comparable with dipole-dipole broadening.
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