Three series of novel 3-methyl-2-alkylthio benzothiazolyl ionic liquids (ILs) were synthesized for the first time. After structural identification, their melting point, solubility, and thermostability together with antibiotic activity were determined successively. As a result, 3-methyl-2-alkylthio benzothiazolyl p-toluene sulfonate was found to have the highest antibacterial activity among the three series of ILs. Meanwhile, it has a good solubility in water as well. On the basis of comprehensive comparison with similar compounds, the effect of cations and anions of these benzothiazolium ILs on typical physical properties together with antibiotic performance was explored and discussed, which is very beneficial to take the greatest advantage of their structural designability for various purposes. Furthermore, the experiment data preliminarily discovered the relationships of the structure-properties/activities of the above three kinds ILs to a certain extent, which can provide useful references for future research and for the potential application of these new ILs as surfactant antiseptics or agricultural chemicals.
Four tropine-based ionic liquids with the anion of PF6-were synthesized and their hydrophilicity/hydrophobicity was evaluated according to the solubility determination in water. Then the empirical equation model, the λh model, the NRTL model and Wilson model were used to correlate the solubility data. Among them the empirical equation model showed the best correlation result. At last, the ILs were used to prepare the gel sorbent material for potential use in chemical, environmental or pharmaceutical fields.
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