Bone remodelling and bone loss are controlled by a balance between the tumour necrosis factor family molecule osteoprotegerin ligand (OPGL) and its decoy receptor osteoprotegerin (OPG). In addition, OPGL regulates lymph node organogenesis, lymphocyte development and interactions between T cells and dendritic cells in the immune system. The OPGL receptor, RANK, is expressed on chondrocytes, osteoclast precursors and mature osteoclasts. OPGL expression in T cells is induced by antigen receptor engagement, which suggests that activated T cells may influence bone metabolism through OPGL and RANK. Here we report that activated T cells can directly trigger osteoclastogenesis through OPGL. Systemic activation of T cells in vivo leads to an OPGL-mediated increase in osteoclastogenesis and bone loss. In a T-cell-dependent model of rat adjuvant arthritis characterized by severe joint inflammation, bone and cartilage destruction and crippling, blocking of OPGL through osteoprotegerin treatment at the onset of disease prevents bone and cartilage destruction but not inflammation. These results show that both systemic and local T-cell activation can lead to OPGL production and subsequent bone loss, and they provide a novel paradigm for T cells as regulators of bone physiology.

Abstract. Triaxial compression experiments were conducted to investigate the inelastic and failure behavior of six sandstones with porosities ranging from 15% to 35%. A broad range of effective pressures was used so that the transition in failure mode from brittle faulting to cataclastic flow could be observed. In the brittle faulting regime, shear-induced dilation initiates in the prepeak stage at a stress level C' which increases with effective mean stress. Under elevated effective pressures, a sample fails by cataclastic flow. Strain hardening and shear-enhanced compaction initiates at a stress level C* which decreases with increasing effective mean stress.The critical stresses C' and C* were marked by surges in acoustic emission. In the stress space, C* maps out an approximately elliptical yield envelope, in accordance with the critical state and cap models. Using plasticity theory, the flow rule associated with this yield envelope was used to predict porosity changes which are comparable to experimental data. In the brittle faulting regime the associated flow rule predicts dilatancy to increase with decreasing effective pressure in qualitative agreement with the experimental observations. The data were also compared with prediction of a nonassociative model on the onset of shear localization. Experimental data suggest that a quantitative measure of brittleness is provided by the grain crushing pressure (which decreases with increasing porosity and grain size). Geologic data on tectonic faulting in siliciclasfic formations (of different porosity and grain size) are consistent with the laboratory observations.

No abstract

No abstract

No abstract

[1] We investigated the frictional sliding behavior of simulated quartz-clay gouges under stress conditions relevant to seismogenic depths. Conventional triaxial compression tests were conducted at 40 MPa effective normal stress on saturated saw cut samples containing binary and ternary mixtures of quartz, montmorillonite, and illite. In all cases, frictional strengths of mixtures fall between the end-members of pure quartz (strongest) and clay (weakest). The overall trend was a decrease in strength with increasing clay content. In the illite/quartz mixture the trend was nearly linear, while in the montmorillonite mixtures a sigmoidal trend with three strength regimes was noted.Microstructural observations were performed on the deformed samples to characterize the geometric attributes of shear localization within the gouge layers. Two micromechanical models were used to analyze the critical clay fractions for the two-regime transitions on the basis of clay porosity and packing of the quartz grains. The transition from regime 1 (high strength) to 2 (intermediate strength) is associated with the shift from a stresssupporting framework of quartz grains to a clay matrix embedded with disperse quartz grains, manifested by the development of P-foliation and reduction in Riedel shear angle. The transition from regime 2 (intermediate strength) to 3 (low strength) is attributed to the development of shear localization in the clay matrix, occurring only when the neighboring layers of quartz grains are separated by a critical clay thickness. Our mixture data relating strength degradation to clay content agree well with strengths of natural shear zone materials obtained from scientific deep drilling projects.

The hydrostatic compaction behavior of a suite of porous sandstones was investigated at confining pressures up to 600 MPa and constant pore pressures ranging up to 50 MPa. These five sandstones (Boise, Kayenta, St. Peter, Berea, and Weber) were selected because of their wide range of porosity (5–35%) and grain size (60–460 μm). We tested the law of effective stress for the porosity change as a function of pressure. Except for Weber sandstone (which has the lowest porosity and smallest grain size), the hydrostat of each sandstone shows an inflection point corresponding to a critical effective pressure beyond which an accelerated, irrecoverable compaction occurs. Our microstructural observations show that brittle grain crushing initiates at this critical pressure. We also observed distributed cleavage cracking in calcite and intensive kinking in mica. The critical pressures for grain crushing in our sandstones range from 75 to 380 MPa. In general, a sandstone with higher porosity and larger grain size has a critical pressure which is lower than that of a sandstone with lower porosity and smaller grain size. We formulate a Hertzian fracture model to analyze the micromechanics of grain crushing. Assuming that the solid grains have preexisting microcracks with dimensions which scale with grain size, we derive an expression for the critical pressure which depends on the porosity, grain size, and fracture toughness of the solid matrix. The theoretical prediction is in reasonable agreement with our experimental data as well as other data from soil and rock mechanics studies for which the critical pressures range over 3 orders of magnitude.

Abstract. The three-dimensional geometry and connectivity of pore space controls the hydraulic transport behavior of crustal rocks. We report on direct measurement of flow-relevant geometrical properties of the void space in a suite of four samples of Fontainebleau sandstone ranging from 7.5 to 22% porosity. The measurements are obtained from computer analysis of three-dimensional, synchrotron X-ray computed microtomographic images. We present measured distributions of coordination number, channel length, throat size, and pore volume and of correlations between throat size/pore volume and nearest-neighbor pore volume/pore volume determined for these samples. In order to deal with the ambiguity of where a nodal pore ends and a channel begins, we apportion the void space volume solely among nodal pores, with the channel throat surfaces providing the nodal pore delineations. Pore channels thus have length but no associated volume; channel length is defined by nodal pore center to nodal pore center distance. For a sample of given porosity our measurements show that the pore coordination number and throat area are exponentially distributed, whereas the channel length and nodal pore volume follow gamma and lognormal distributions, respectively. Our data indicate an overall increase in coordination number and shortening of pore channel length with increasing porosity. The average coordination number ranges from 3.4 to 3.8; the average channel length ranges from 200 to 130/•m. Average throat area increases from 1600 to 2200/•m 2 with increasing porosity, while average pore volume remains essentially unchanged at around 0.0004 mm a.