Vital physiological and metabolic processes occurring in the human body are associated with free radical oxidation, which affects the structure, permeability and physico-chemical properties of biological membranes. Horse sorrel is used for scurvy, gout, diabetes, jaundice, hypertension, rheumatism, skin diseases – scabies, lichen, eczema, burns, as well as diseases of the digestive and cardiovascular systems. The purpose of the research: to study the technology of obtaining liquid extract of horse sorrel roots and to study its antioxidant activity on the body. Liquid extract of horse sorrel roots and auxiliary substances were used as the object of the study: dimethyl sulfoxide DMSO, ethyl alcohol 96%, quercetin, lecithin. When performing the work, equipment was used: liquid chromatograph "Color Yauza-01-AA", SF-LEKISS 1207UV. The object of the study of the total antioxidant activity were extracts of horse sorrel roots obtained using ethyl alcohol in concentration: 30%, 40%, 50%, 60%, 70%, 80%. The total content of antioxidants in the studied liquid extracts of horse sorrel roots was determined by two methods: using a liquid chromatograph "Color Yauza-01-AA" with an amperometric detector. The quantitative content of antioxidants was determined according to the calibration schedule. The conversion was carried out for gallic acid and quercetin. Using a model of iron-induced lipid peroxidation in the system of lecithin (phosphotidylcholine) liposomes, the studied liquid extracts were evaluated by reducing the accumulation of peroxide compounds. The study was carried out at a concentration of 200 mcg/ml to 500 mcg/ml of horse sorrel extract and increasing the dose.
The mortality rate due to cardiovascular pathologies occupies a significant place. Reduced vascular resistance is the cause of diseases - coronary heart disease, atherosclerosis, chronic and acute cerebral circulatory insufficiency, retinopathy, etc. Increasing vascular resistance to free radical, atherosclerotic, toxic, autoimmune and other types of damage is the most urgent task of treatment and prevention of vascular and many other destructive diseases of the central nervous system. Ceylon cinnamon is widely used in inflammatory processes, has antispasmodic, analgesic, tonic, antiseptic properties, is used for disorders of the gastrointestinal tract, and is also a natural antibiotic, improves memory and concentration. By chemical composition, Ceylon cinnamon contains B vitamins, as well as macro- and microelements: iron, potassium, copper, phosphorus, selenium, sodium, calcium, zinc. The object of the study is a liquid extract of Ceylon cinnamon obtained by extraction using 70% ethyl alcohol. A method of quantitative determination for proanthocyanidins in a liquid extract of Ceylon cinnamon has been developed, which is based on the acid cleavage of proanthocyanidins in the presence of a catalyst (Fe3+ ions) to anthocyanidins. During the experiment, it was found out that the extract under study has an anti-inflammatory activity superior to the tincture of sabelnik and its angioprotective activity is proved to be significantly higher than the comparison drug "Blueberry Forte" produced by the pharmaceutical company "Evalar". The obtained research results show the prospects of using Ceylon cinnamon extract liquid for the prevention and treatment of vascular diseases.
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