Através do estudo da musculatura-lisa da parede da veia central das supra-renais de chagásicos crônicos foram identificados núcleos em 18 dentre 40 células parasitadaspelo Trypanosoma cruzi. Com o auxílio de uma ocular micrométrica foram tomados dois diâmetros de cada ninho e núcleo, obtendo-se suas médias e desvios padrões (25,7 jum ± 17,2 e 12 p-m ± 5,3 e 7,5 fim ± 2,82 para diâmetros dos ninhos e dos núcleos para célu las mononucleadas e binucleadas respectivamente). A relação diâmetro do núcleo/diâ metro do ninho fo i de 0,5 ± 0,16. 83,3% dos ninhos eram mononucleados e apenas 16,7% binucleados. A média do volume nuclear para as células parasitadas foi de 1204fim3 ± 807,0 e para as células musculares lisas não parasitadasfoi de69,6/im ± 7,2. A forma e o contorno nucleares eram variados e irregulares. Os núcleos hipercromáticos ou vesiculosos, com membrana cromatínica geralmente espessa e bem defi nida, freqüentemente mostrando um a dois nucléolos por secção, podendo, no entanto, serem encontrados até 8 nucléolos. Sendo as alterações nucleares descritas freqüentes nos chagásicos crônicos, épossível que sejam a expressão morfológica de importantes interações entre o T. cruzi e o leiomiócito.
In the acquired immunodeficiency syndrome (AIDS), the adrenal glands are subject to opportunistic infections, neoplasm or direct cytopathic effect by HIV. It is know that the incidence and type of adrenal involvement vary according to the patient's place of origin. In this paper we evaluate adrenal involvement in fourteen patients that died from AIDS in the University Hospital of Uberaba, Brazil. The group studied was comprised of thirteen males and thirteen whites. The age was 29.9 +/- 7.8 years, and the body mass index was 19.0 +/- 4.1 kg/m2. Adrenal specimens obtained from autopsies were analyzed by light microscopy. Inflammation was found in 100% of the cases and the etiologic agent(s) was (were) identified in eight (58.1%) patients. Cytomegalovirus was identified in seven cases, Cryptococcus sp and Herpes simplex in two and Histoplasma sp in one case, these pathologic findings were similar to literature. We also found parenchymal calcification and adrenal central vein phlebitis in one case each. Injury was found in some cases without identified infections agent. This fact could be due to the direct cytopathic effect by HIV, or due to toxicity of drug therapy used during treatment of AIDS and opportunistic infections.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.