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Ophiobolosin A and ophiobolosin B have been isolated as metabolites of Cochliobolus miyabeanus from the mycelia cultured on the different media. The former is identical with zizanin (C29H4O5) and the new molecular formula, C25H38O4 is presented. They have a biological effect to inhibit the germination and the growth of Oryza sativa seeds and also an antifungal activity against Trichophyton spp. Here is reported the isolation, some physical and chemical properties and biological activities of ophiobolosins.

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From the mycelium of Ascochyta imperfecta decumbin, C16H24O4, mp 203•Ž, [ƒ¿]_??_+91.7•‹ was obtained in one percent yield.