Psoriasis is an autoimmune, chronic disease determined by environmental and genetic factors. The occurrence of psoriasis is accompanied by metabolic diseases, cardiovascular diseases (CVD) and depression, disturbances on interpersonal interactions and a tendency towards social isolation. Regardless of the form of psoriasis and the severity of the disease, early arterial lesions are recorded in arterial vessels of patients. Nevertheless, the chance of CVD is higher in the population of patients with severe psoriasis than in patients with mild to moderate psoriasis. The correlation between the presence of atherosclerotic plaque and psoriatic plaque is partially explained by: (1) a similar inflammatory pathway-via the T helper cells, (2) impaired angiogenesis, and (3) endothelial dysfunction. In the considered tests, the diagnostic tools used showed a reduced level of endothelial progenitor cells in the circulation of patients with psoriasis. Endogenous angiopoietin stimulation in patients with psoriasis leads to deterioration of endothelial regeneration, atherosclerosis which secondarily contributes to the progression of heart failure. Clinical and experimental data confirm the potential of immunomodulatory methods to combat both autoimmune and cardiovascular diseases through the use of immunosuppressive drugs. Full understanding of the way in which CVD develops in patients with autoimmune diseases would enable the implementation of targeted cell therapy allowing the quality and life expectancy of patients to be improved. Modern cellular diagnostic tools allow the use of highly specific biomarkers, which in the near future will enable a reduction in morbidity and mortality due to CVD.
Introduction: Gabapentin is a drug used for monotherapy or adjunctive therapy of simple and complex partial epileptic seizures in adults and children. It is also used to treat neuropathic pain for adults. There are reports in the medical literature of the effective use of gabapentin in the treatment of other conditions. Let's take a closer look at its therapeutic potential.Aim of the study: The overview of current literature knowledge about the usage of gabapentin in various medical conditions within the fields of toxicology, dermatology, gynecology, psychiatry branches' issues, with indicating the potential abuse. Materials and Methods: We reviewed the literature available in the PubMed database, using the keywords.Results: Gabapentin is an anticonvulsant drug structurally similar to gamma-aminobutyric acid (GABA). It is considered to be a centrally acting analog of GABA, nevertheless, it presents a different molecular mechanism comparing to the other drugs that affect GABA-ergic transmission. The registered indications for its use are the treatment of seizures within adults and children and neuropathic pain in adults. The literature reveals that gabapentin is also used in the treatment of alcohol abuse disorders within the patients with alcohol withdrawal symptoms, the treatment of pruritus, hot flashes during menopause and the treatment of anxiety disorder. Summary: Due to the ambiguous effects of gabapentin usage, it can be applied to treat various medical conditions. Nevertheless, the usage of this drug described in the literature requires additional studies on a larger group of patients to confirm the findings.
Introduction: Contrast-induced nephropathy is one of the most serious adverse effects of radiocontrast agents usage. It is currently listed in the literature as the third most common cause of iatrogenic acute kidney injury. Aim of the study: The aim of this study is to provide an overview of the extent, severity and prevention of CIN. It is to shed a broader light on this disease entity and be a helpful resource in the future for other clinicians struggling with CIN. Methods and materials: A literature review was conducted using the PubMed database, using the keywords: "contrast-induced nephropathy"; "acute kidney injury"; "contrast media". Results: Pathogenesis of CIN is not entirely clear. There are many risk factors being e.g. diabetes, chronic kidney disease, advanced age (patients over 75 years old). Prevention methods include restricting contrast volume to a minimum, balancing the patient's volaemia before contrast administration or perioperative saline hydration to normalise volaemia. Conclusion: CIN is a significant health problem, which can be a life threat. Despite the fact that the exact pathogenesis of the condition still remains unknown, the CIN prophylaxis becomes more and more effective due to better recognition of risk factors and the usage of adequate prevention measures appropriate to the patients' condition. More studies, with larger test groups, are needed to better define both the pathomechanism of contrast-induced acute kidney injury and new, more effective ways of prevention and treatment of this condition.
Introduction: Cardiovascular diseases (CVDs) remain major problem in modern medicine. According to World Health Organization they are the leading cause of death. Despite increased awareness about impact of healthy lifestyle, mortality still remains on high level. Cardiovascular diseases requires multidisciplinary treatment. One of those aspects is determinate an appropriate diet. Purpose: The aim of this systemic review is to collect, evaluate and summarize the information on fasting mimicking diets and it is effect on therapy and prevention in cardiovascular diseases. Material and methods: Analysis and review of available literature. The search of articles in popular scientific databases such as PubMed, Google Schoolar WHO database State of knowledge: Risky behavior include unhealthy diet, tobacco use, physical inactivity, alcohol abuse. Those behaves lead obesity, raised blood pressure, hyperglycemia, dyslipidemia. Those factors have significant impact on the increase of cardiovascular diseases in the population. Fasting and calorie restriction are becoming more and more popular. Results: Many studies indicate that fasting mimicking diet can prevent from excessive fat accumulation, obesity, diabetes, dyslipidemia, hypertension As a result it decreases probability of cardiovascular diseases. Those diets not only support weight loss, but also can help maintain good health and extend lifespan.
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