Selective and efficient analytical methods are required not only for quality assurance but also for authentication of herbal formulations. In the present study, high-performance liquid chromatography (HPLC) detection was developed for chromatographic fingerprint analysis of the extract from grounded plant materials of Jamu Diabetes (JD), a well known herbal formulation in Malaysia. The bioactive markers rosmarinic acid, curcumin, cinnamaldehyde and andrographolide were identified from the methanol/water (80:20) extract of JD materials. The data presented in this study showed that the developed method is simple, sensitive and specific for simultaneous determination of the indicated marker compounds either qualitatively or quantitatively, and may be used as a fingerprint profile for the standardization of extractives or herbal medicines from herbal formulation JD materials.
Herbal medicine is usually made using dry powdered herbs in the form of capsule. Capsule form herbal supplement suffers lower shelf life as compared to compact herbal powder in tablet form. In this study, Diabecine™, a blend of herbal medicine traditionally used as herbal supplement for diabetic patients was selected and transformed into a compressed tablet. Direct compression method and minimal usage of excipients were the aims of this study. By using direct compression, the blend of 40% fine powder herbs and 60% of excipients performed the best and fulfill the pharmaceutical standard. The safety data of microbial and heavy metal testing obtained met the safety requirements for herbal supplement category under the National Pharmaceutical Control Bureau of Malaysia. In conclusion, the tablet formulation of Diabecine TM is suitable to be manufactured by using direct compression method. This research implicates the possibility of producing tablets with high dose of herbal powder by direct compression method.
Herbal extracts are known for their antioxidant, antimicrobial, and anti–inflammatory properties. However, the intense colour caused by their phenolic content and dark–coloured compounds may spoil the final product’s appearance. To remedy that, this study was undertaken to design a decolourization device to eliminate the intense colour of herbal extracts while retaining their beneficial properties. Batch experiments have been conducted to study decolourization and its effect on extract quality. From there, a decolourization device has been devised using activated carbon. Operating at optimum conditions, the device was able reduce 81 % of the total phenolic content of cashew leaf extracts while retaining 88 % of its radical scavenging capacity. Furthermore, the device is able to re–design the extract’s colour to fulfill the end–user’s needs by manipulating the contact period. The design of this device best fits Langmuir isotherm which demonstrates monolayer coverage of adsorbate at the outer surface of activated carbon.
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