Holistic care means addressing the patient as a person; providing high-quality care by focusing on individual needs. Our goal is to implement a survey that quantifies the patients' physical, mental, and spiritual health to enable improvements in client-centered therapy in lower-limb amputees. For this, we worked with a 43-year-old Hispanic male with a medical history of insulin-dependent diabetes complicated by sequential lower limb amputations. The second amputation cost him his job and left him homeless. The patient was hospitalized after developing severe depression, to the point that he had command auditory hallucinations to kill himself. He was discharged back into the community after a three-week hospitalization. However, he was readmitted to the hospital a week later due to a resurgence of suicidal ideation. Our team engaged the patient using the "Holistic Health and Wellness Survey" of Raymond W. Smith, which we used to assess and address various domains of his mental, spiritual, and physical health. We were able to create obtainable goals for the patient for each category on which he scored low in the health and wellness survey. The patient's overall health and attitude improved substantially through his client-centered therapy, which addressed his quantified health needs; and he began to take an active role in developing short-and longterm goals that he found attainable as he adjusted to life as a double-amputee.This case illustrates the potential for improving client-centered therapy in lower-limb amputees. We believe that providers may benefit from implementing this health and wellness survey to better assess how to provide client-centered care for their patients.
BACKGROUND YouTube is a popular platform with many videos which have potential educational value for medical students. Due to the lack of peer review, other surrogates are necessary to determine the content quality of such educational videos. Few studies have analyzed the research background of the physicians associated with the production of YouTube videos for medical education. The research background of those physicians may be a reflection of the content quality of these educational videos. OBJECTIVE This study identifies physicians associated with the production of educational YouTube videos about shingles and analyzes the physicians based on their research background. METHODS Using the YouTube search engine with default settings, the term “shingles” was searched on May 8, 2020. A cross-sectional study was performed using the first 50 search results. A search on Scopus for each identified physician was performed and data regarding their research background was recorded. RESULTS Of the 50 YouTube videos, 35 (70%) were categorized as academic. From the academic videos, 24 (71%) featured physicians totaling 25 physicians overall. Five physicians (20%) had at least 1 shingles-related publication. Eight physicians (32%) had an h-index >10. Twenty-one physicians (84%) held an academic affiliation. CONCLUSIONS These results ensure to a certain degree the quality of the content in academic videos on YouTube for medical education. However, more evaluation is needed for this growing platform.
Despite significant advances in biology and medicine, the incidence and mortality due to cancer world-wide is still unacceptably high. With the goal of detection and eradication of disease, our overall strategy had been to identify a novel molecular indicator, Epithelial Membrane Protein 2 (EMP2), which is ‘targetable' and ‘permeable'. EMP2 is a tetraspan protein that is expressed in a distinct subset of several cancers including breast, endometrial, ovarian, and brain. For instance, EMP2 expression is increased in 65% of breast cancer patients, independent of hormone receptor status and human epidermal growth factor receptor-2 (HER2) expression. EMP2 levels are elevated in early cancer lesions as well as during tumor progression and in metastasis. These factors allowed us to propose utilizing EMP2 as a target for cancer therapy of EMP2 positive tumors. We have previously shown that an anti-EMP2 IgG1 is successful at reducing breast and endometrial cancer tumor load. As the antibody-antigen complex rapidly internalizes, we have created an anti-EMP2 drug conjugate to improve on the efficacy of the naked antibody. Our second generation antibody includes the toxin monomethyl auristatin (MMAE), a potent microtubule-disrupting toxin, conjugated to the fully human anti-EMP2 IgG1 through both the protease cleavable linker and chemical non-cleavable linker. In this conjugation strategy, MMAE was conjugated using Click Chemistry reaction to the hinge region of the anti-EMP2 IgG1 antibody through rebridging disulfide bond technology to improve ADC stability, homogeneity, and especially pharmacological properties in vivo. The resulting anti-EMP2 IgG-MMAE ADC efficacy was evaluated and compared to the naked antibody in the aspect of antigen binding and specificity as well as in vitro cytotoxic effects. In vivo, the anti-EMP2 ADCs were evaluated for serum stability and anti-tumor efficacy. Anti-EMP2 IgG1 drug conjugate exhibits potent in vitro binding, internalization and cytotoxicity on a number of EMP2 positive and negative cancer cell lines. As a successful proof of principle, both the cleavable and non-cleavable anti-EMP2 IgG1-MMAE antibodies showed potent cytotoxic effects using a panel of cell lines including breast, ovarian, and endometrial cancer cells with an EC50 at least 10 times less than that required for the naked antibody. Currently, we are evaluating the anti-tumor efficacy of the antibody in vivo with the ultimate goal of showing that the anti-EMP2 drug conjugate improves survival as a single agent with minimal to no toxicity. Acknowledgement: Funded by the UCLA Tumor Cell Biology Training Program (USHHS Ruth L. Kirschstein Institutional National Research Service Award # T32 CA009056) and Citation Format: Shabnam Mohandessi, Teevit Dunnsiri, Chinmayi Aryasomayajula, Madhuri Wadehra. Anti-EMP2 IgG Mono Methyl Auristatin E (MMAE) antibody-drug conjugate (ADC) as a potential cancer therapeutic. [abstract]. In: Proceedings of the AACR Precision Medicine Series: Targeting the Vulnerabilities of Cancer; May 16-19, 2016; Miami, FL. Philadelphia (PA): AACR; Clin Cancer Res 2017;23(1_Suppl):Abstract nr B40.
BACKGROUND YouTube is a popular American video-sharing platform that has been accessible to the public since 2005. Previous studies have shown that YouTube is potentially beneficial to medical education, but the quality of videos still need to be determined. OBJECTIVE The goal of this study is to understand the quality of the YouTube videos by evaluating the characteristics of physicians and the total number of views on videos regarding fibromyalgia. METHODS The term “fibromyalgia” was searched on the YouTube search engine by relevance, the default setting. Information from the first 100 videos were analyzed. A search was performed on Scopus to determine the h-index and fibromyalgia-related publication for any physician who was featured in the videos. RESULTS Of the top 100 videos, there were 64 academic videos, 18 vlogs, 5 interview videos, and 13 miscellaneous videos. Out of the 64 academic videos, 30 physicians, 7 Doctors of Philosophy (Ph.D.), 5 physical therapists, and 5 chiropractors were identified. The majority physicians have an adequate academic affiliation such as h-index and academic publications. CONCLUSIONS Residents and medical students will encounter a large number of academic videos on fibromyalgia on YouTube. This study suggests that many videos were posted for academic purposes and that the quality of the videos can be ensured to some degree. However, developing a better systemic evaluation of the quality of YouTube content is still necessary.
BACKGROUND YouTube is a popular American video-sharing platform that has been accessible to the public since 2005. Previous studies have shown that YouTube is potentially beneficial to medical education, but the quality of videos still need to be determined. OBJECTIVE The goal of this study is to understand the quality of the YouTube videos by evaluating the characteristics of physicians and the total number of views on videos regarding fibromyalgia. METHODS The term “fibromyalgia” was searched on the YouTube search engine by relevance, the default setting. Information from the first 100 videos was analyzed. A search was performed on Scopus to determine the h-index and fibromyalgia-related publication for any physician who was featured in the videos. RESULTS Of the top 100 videos, there were 64 academic videos, 18 vlogs, 5 interview videos, and 13 miscellaneous videos. Out of the 64 academic videos, 30 physicians, 7 Doctors of Philosophy (Ph.D.), 5 physical therapists, and 5 chiropractors were identified. The majority of physicians have adequate academic affiliation such as h-index and academic publications. CONCLUSIONS Residents and medical students will encounter a large number of academic videos on fibromyalgia on YouTube. This study suggests that many videos were posted for academic purposes and that the quality of the videos can be ensured to some degree. However, developing a better systemic evaluation of the quality of YouTube content is still necessary.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.