A synthetic strategy
for phenolic lipids such as anacardic acid
and ginkgolic acid derivatives using an efficient and selective redox-relay
Heck reaction followed by a stereoselective olefination is reported.
This approach controls both the alkene position and stereochemistry,
allowing the synthesis of natural and unnatural unsaturated lipids
as single isomers. By this strategy, the activities of different anacardic
acid and ginkgolic acid derivatives have been examined in a matrix
metalloproteinase inhibition assay.
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