Sickle cell disease (SCD) is an autosomal recessive inheritance disorder that affects the beta-globin gene and results in the replacement of the amino acid glutamic acid by valine in the β chain of the hemoglobin molecule, producing erythrocytes with defective forms and functions. A range of pathological conditions is associated with SCD, however, one in particular stands out by gravity. Acute thoracic syndrome (STA), characterized by the presence of pulmonary infiltrates associated with a clinical symptom such as chest pain, cough, wheezing, tachypnea and fever, is considered a leading cause of death in patients with sickle cell disease. Early diagnosis and introduction of an effective approach to complication are needed to improve outcomes and minimize associated morbidity and mortality. Risk factors associated with STA in the SCDAbdominal surgery for splenectomy and cholecystectomy [19] Hypersensitivity [20,21] Smoking [20,21] Asthma [22] Infections [9,[23][24][25] Post-Surgical Hypoventilation [9,[23][24][25] Fatty Embolism [9,[23][24][25]
Celiac disease is a multisystem resistant based issue that is activated by the ingestion of gluten in hereditarily defenseless people. The predominance of celiac disease has ascended in late decades and is at present around 1% in most Western populaces. The explanation behind this ascent is obscure, albeit natural elements identified with the cleanliness speculation are suspected. The pathophysiology of celiac disease includes both the natural and versatile insusceptible reaction to dietary gluten. Clinical components are various and incorporate gastrointestinal side effects, metabolic bone disease, barrenness, and numerous different appearances. In spite of the fact that a sans gluten eating regimen is powerful in many patients, this eating routine can be troublesome and can restrain personal satisfaction; thus, non-dietary treatments are at different phases of improvement. This survey likewise covers non-celiac gluten affectability. The pathophysiology of this clinical phenotype is inadequately seen, however it is a reason for expanding enthusiasm for sans gluten consumes less calories in the overall public. Throughout the most recent decade when the commonness of the disease increments quickly affirming the relationship between coeliac disease and a scope of regenerative issue. Issues here are for the most part affirmed in untreated ladies. Among the atypical side effects of coeliac disease additionally incorporate fruitlessness, for example, deferred onset of monthly cycle, early menopause, optional amenorrhea, barrenness and pregnancy entanglements, for example, repetitive premature births, intrauterine fetal development confinement, little hatchling for gestational age, low birth weight and untimely birth. Celiac disease maybe significant increases in spontaneous abortion, premature delivery, and later age of menarche.
Celiac disease is an autoimmune pathology of a genetic nature triggered by the consumption of gluten and characterized by histological changes in the intestine of genetically arranged patients. The characteristic symptoms of CD are diarrhea, constipation, pain and abdominal distension. Allied to this symptomatic set is the imbalance of the human intestinal tract (GI) microbiome, a complex that has in its composition a range of microorganisms that contributes immensely to the metabolism physiology and to maintain the health of the host.Changes in this system leads to a condition known as dysbiosis, where the intestinal microbiota becomes unbalanced and can trigger numerous gastrointestinal complications, including celiac disease.
Acute Myocardial Infarction (AMI) is one of the leading causes of morbidity and mortality worldwide. The greatest risk of fatality occurs within the first hours of initiation of AMI. Thus, the early diagnosis of cardiac ischemia is fundamental for the effective management of AMI patients. Inadequate diagnosis of patients with chest pain often leads to inadequate admission of patients without AMI and vice versa. In addition to the clinical history, physical examination, accurate electrocardiogram findings, and evaluation of cardiac biomarkers play an important role in the early diagnosis of acute ischemia. The present review discusses in detail the various cardiac biomarkers released during the event of an AMI.
Vulvovaginitis is one of the most troublesome and common gynecological problems affecting a woman's health. Vulvovaginitis can be defined as inflammations that affect the vaginal walls causing local pH changes, pruritus and sometimes secretions. They are caused by bacteria (bacterial vaginosis), fungi (fungal vulvovaginitis), protozoa (trichomoniasis) and also by associated microorganisms called mixed vulvovaginitis.
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