Hyperhidrosis is characterized by excessive sweating and it affects almost 5% of the population. The affected age group is wide, and it can affect from children to elderlies. There are two types of hyperhidrosis: generalized and focal. Treatment depends on the symptoms presented. In more severe cases, radiofrequency sympatholysis and bilateral thoracic sympathectomy are the options. However, recurrence is possible or the postoperative appearance of conditions called compensatory hyperhidrosis or reflex hyperhidrosis. We describe two cases of patients treated with Cannabidiol who had significant and unexpected improvement of hyperhidrosis. The first patient received Cannabidiol specific for public presentations at work, and the second patient had a diagnosis of autism spectrum disorder. The hyperhidrosis improved in both patients immediately after using Cannabidiol.
L-methylfolate, a new option in psychiatric treatment, would it be linked to psoriasis relapse? L-metilfolato, uma nova opção no tratamento psiquiátrico, estaria ligado à recaída de psoríase?
Com uma forte predisposição genética, traços patogênicos autoimunes e com grande relação ao meio ambiente, a psoríase é uma doença crônica, não infecciosa, que acomete pessoas de todas as idades, sem predileção por sexo. O seu tratamento tem como principal objetivo controlar a diferenciação e a proliferação dos queratinócitos. Tendo isso em vista, o objetivo desta revisão narrativa é fazer uma análise do que já está documentado na literatura, envolvendo os efeitos da Cannabis sativa no tratamento da psoríase, com enfoque na sua efetividade. Para isso, foi feita uma busca ativa sobre o tema nas bases de dados Google Acadêmico, Pubmed e LILACS. Foi verificado que os canabinoides possuem um potencial terapêutico na psoríase, principalmente em relação à proliferação dos queratinócitos e na modulação da inflamação, porém a maioria dos estudos disponíveis são in vitro. É necessário a realização de mais estudos clínicos em humanos para melhor elucidação da eficácia e segurança dos canabinoides no tratamento da psoríase.
Coronavirus disease 2019 (COVID-19) is a major issue of our times. Many aspects and features of this new and complex disease are being described on a daily basis. Major endpoints are systemic inflammation, markedly characterized by the cytokine storm, respiratory failure, and coagulation disorders, such as thrombophilia. In its terms, thrombophilia has a major impact on the COVID-19 prognosis. With regard to this, paying attention on molecular variants, such as DNA polymorphisms, epigenetic factors, and other biomarkers, could be an important approach to optimizing and personalizing the treatment of patients according to their inherited thrombotic features. This chapter brings an overview on the three major DNA polymorphisms associated with thrombophilia and proposes that these same biomarkers could be used in pretreatment screenings of patients with COVID-19 to seek the most appropriate therapy for each individual molecular profile.
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