Background: A potential GTPase-activating protein (GAP) regulates the activity of Rab27B in pancreatic acinar cells. Results: Overexpression of EPI64B specifically decreases the level of active Rab27B and enhances secretion. Conclusion: EPI64B acts as a Rab27B GAP in pancreatic acinar cells and regulates secretion. Significance: Deciphering functions of EPI64B can deepen our understanding in how Rab27B is regulated.
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