Objective: to study the immune mechanisms of inflammation of the patients with BA in association with type 2 diabetes mellitus (DM). Materials and methods: the study involved 215 patients with persistent BA of moderate severity at the age of (28.6±2.4) years, including 88 men (40.9%), 127 women (59.1%). Among the examined patients with BA there were 64 — group I, persons with BA in association with type 2 diabetes — 151 (group II), in whom, along with routine laboratory and instrumental methods, cellular immunity, IgE and lymphocytic autoantibodies were determined. Results: patients with BA in combination with type 2 diabetes more often have an uncontrolled course of the disease with a complication in the form of grade II respiratory failure. In patients with BA, as well as with BA in combination with type 2 diabetes, the formation of secondary immunodeficiency due to the cellular link was noted. The combination of BA and type 2 diabetes is characterized by the most pronounced negative changes in cellular immunity among all examined patients. In BA in combination with type 2 diabetes, a decrease in the concentration of IgE was noted along with an increase in the number of lymphocytic autontibodies. Conclusion: patients with BA in combination with type 2 diabetes have a more severe course of BA and the addition of a more destructive autoimmune to allergic inflammation, which increases the risk of complications of both diseases.
The sTaTe of cellular immuniTY in paTienTs WiTh chronic oBsTrucTiVe pulmonarY Disease, comBineD WiTh osTeoarThriTis skiba T. a. lugansk state medical universitу, ukraine Сочетание хронической обструктивной болезни легких (ХОБЛ) и остеоартроза (ОА) часто встречается в клинической практике, ограничивая возможности физической реабилитации пациента. Выраженность системного воспалени я при каждом из коморбидных заболеваний определяет состояние иммунной системы, Оригинальные исследОвания Внутренние болезни original research
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