Kynurenine disbalance induced by mutations of the kynurenine path of tryptophan metabolism in drosophilae has an effect on the locomotor behavior of larvae. Excessive concentrations of kynurenic acid in the cinnabar mutant caused a dramatic decline in the activity. The effects of mutations apparently depend on the modulatory effect of kynurenines on the signal pathways regulated by ionotropic glutamatergic and cho linergic receptors. The age dynamics of their genes' expression is evidence for progressive development of dis orders induced by kynurenine disbalance.
Disbalance of kynurenines produced by Drosophila mutations of the kynurenine pathway of tryptophan metabolism influences the locomotor behavior in larvae. The most pronounced is the effect of accumulation of kynurenic acid in the mutant cinnabar manifested as sharp reduction of general level of locomotor activity. The mutations seem to act through modulatory influences of kynurenines on signal cascades governed by ionotropic glutamatergic and cholinergic receptors. Expression of receptor genes in the mutants shows age-related changes pointing to gradual evolvement of consequences of kynurenines disbalance.
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