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One of the challenges in computational fluid-structure interaction (FSI) analysis of spacecraft parachutes is the "geometric porosity," a design feature created by the hundreds of gaps and slits that the flow goes through. Because FSI analysis with resolved geometric porosity would be exceedingly time-consuming, accurate geometric-porosity modeling becomes essential. The geometric-porosity model introduced earlier in conjunction with the space-time FSI method enabled successful computational analysis and design studies of the Orion spacecraft parachutes in the incompressible-flow regime. Recently, porosity models and ST computational methods were introduced, in the context of finite element discretization, for compressible-flow aerodynamics of parachutes with geometric porosity. The key new component of the ST computational framework was the compressible-flow ST slip interface method, introduced in conjunction with the compressible-flow ST SUPG method. Here, we integrate these porosity models and ST computational methods with isogeometric discretization. We use quadratic NURBS basis functions in the computations reported. This gives us a parachute shape that is smoother than what we get from a typical finite element discretization. In the flow analysis, the combination of the ST framework, NURBS basis functions, and the SUPG stabilization assures superior computational accuracy. The computations we present for a drogue parachute show the effectiveness of the porosity models, ST computational methods, and the integration with isogeometric discretization.

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The circulating tumor cell (CTC) test has recently become popular for evaluating prognosis and treatment efficacy in cancer patients. The accuracy of the test is strongly dependent on the precision of the cancer cell separation. In this study, we developed a multistage microfluidic device to separate cancer cells from a red blood cell (RBC) suspension using inertial migration forces. The device was able to effectively remove RBCs up to the 1% hematocrit (Hct) condition with a throughput of 565 μL min(-1). The collection efficiency of cancer cells from a RBC suspension was about 85%, and the enrichment of cancer cells was about 120-fold. Further improvements can be easily achieved by parallelizing the device. These results illustrate that the separation of cancer cells from RBCs is possible using only inertial migration forces, thus paving the way for the development of a novel microfluidic device for future CTC tests.