Chlorogenic acids (CGA) in green coffee bean extract (GCE) reduce blood pressure in spontaneously hypertensive rats and humans. The authors examined the blood pressure-lowering effect and safety of CGA in patients with mild hypertension through a placebo-controlled, randomized clinical trial. Subjects (n = 28) were randomized to receive treatment with CGA (140 mg/day) from GCE or placebo. Blood pressure, pulse rate, body mass index, routine blood test, hematochemistry, urinalysis, and subjective symptoms were recorded throughout the study. In the CGA group, but not the placebo group, blood pressure (systolic and diastolic) decreased significantly during the ingestion period. There was no difference in body mass index and pulse rate between groups, nor were there any apparent side effects. Thus, CGA from GCE is effective in decreasing blood pressure and safe for patients with mild hypertension.

Tea catechins are plant-derived compounds that improve immune functions. Previous randomized control trials have demonstrated the efficacy of primarily epi-type catechins against upper respiratory tract infections (URTIs). Green tea can be consumed in several ways, including popular bottled beverages. These beverages, however, require sterilization during manufacturing, which results in catechin isomerization. We conducted a randomized, double-blinded, placebo-controlled trial involving healthy Japanese participants to evaluate whether catechin consumption via bottled beverages has an alleviating effect on the duration and severity of URTIs in winter. The catechin group (490 mg catechin, 0.14%, containing 59% epi-type catechin, n = 55) showed reduced durations of running nose, nasal congestion, and headache, compared with the placebo group (0 mg catechin, n = 54; p = 0.013, 0.018, and <0.001, respectively). Furthermore, when considering physical symptoms, the duration of nasopharyngeal symptoms improved significantly in the catechin group (p < 0.001) compared with that in the control group. The daily consumption of catechin thus reduced the duration and severity of URTIs in healthy men and women. Humans are regularly exposed to several potential infectious threats, and the oral administration of heat-epimerized tea catechins might help prevent and reduce the severity of URTIs.

carton (30 cans) of chlorogenic acid-enriched coffee and were encouraged to consume one can each day, and record their weight and coffee consumption using a web-based weight-recording system. The chlorogenic acid-enriched coffee showed high consumer acceptability. The mean weight change at Week 12 was −1.06 kg (95% confidence interval: −0.96, −1.16). Weight loss was significantly greater in obese participants compared with those with normal body mass index (<25 kg/m 2 ) in both men and women. Changes in weight at Week 12 showed a significant dose-response relationship (p<0.001, n=1659). The habitual consumption of chlorogenic acid-enriched coffee together with the use of a weight-recording system was effective for achieving weight loss in daily life. The popularity of drinking Abstract Abdominal obesity is considered a fundamental cause of metabolic syndrome. It has been reported that continuous consumption of chlorogenic acid, which is a major component of coffee polyphenols, reduces abdominal fat together with body weight in humans. Chlorogenic acid-enriched ready-todrink coffee has been developed recently. The antiobesity function of chlorogenic acid-enriched coffee has been demonstrated in some clinical trials; however, the efficacy of this coffee in daily life, which is more relevant in terms of consumer health, remains unknown. This paper describes a large single-arm study of the acceptability and effectiveness of chlorogenic acid-enriched coffee in terms of weight loss. Participants received one free 1 3 104 coffee was developed by Kao Corporation under the brand name Healthya™. It contains 270 mg chlorogenic acid per can (185 g) with reduced hydroxyhydroquinone. Regular coffee contains approximately 35-175 mg per cup [19]. Canned beverages, including soft drinks such as fruit juice, carbonated beverages, green tea and brewed coffee, are very popular in Japan [20], and can be easily purchased at many types of retailer and vending machines. Canned coffee has the second largest share of the soft drink market in Japan, after carbonated beverages [21]. A canned coffee product with an anti-obesity function is therefore an ideal product to support a population-based public health strategy [22]. The anti-obesity function of chlorogenic acidenriched coffee has been demonstrated in some clinical trials [17, 18], therefore it has been approved as a food for specified health use (FOSHU) by the Consumer Affairs Agency, Government of Japan, as a part of product development. However, the efficacy of the coffee in daily life, which is more relevant in terms of consumer health, remains unknown. The purpose of this study was to assess the acceptability and effectiveness of chlorogenic acid-enriched coffee in terms of weight loss in daily life through a large single-arm study. Materials and methods Test beverageThe test beverage is a canned coffee already on the Japanese retail market (Healthya coffee) which contains 185 g of brewed coffee without milk and sugar.The coffee is brewed from roasted coffee beans using 2.5 times...

べく， 新たな定量法を検討した14）