The Nikon Corporation was able to further improve the surface characteristic of titanium by developing a hydroxyapatite (HA) film on an anodic oxide layer of pure titanium implant (SA treatment). The HA film was composed of an electolytic solution containing Ca and P that underwent anodic oxidation followed by hydrothermal treatment in high pressure steam. This study was conducted to investigate how SA treated implants affect the surrounding bone tissue by analyzing them under an electron probe X-ray microanalyzer (EPMA). HA plasma sprayed pure titanium implants, titanium plasma sprayed pure titanium implants, and SA treated titanium plasma sprayed pure titanium implants were implanted in the mandibles of beagles. After four weeks, the surrounding bone tissues were analyzed according to the distribution of Ca and P by EPMA. The results showed that newly-formed bone had a relatively lower density of Ca and P than the existing bone for all dogs. Titanium plasma sprayed pure titanium implants without SA treatment were found to have less geographical distribution for both Ca and P. The Ca/P ratio showed no significant differences among them, indicating that SA treatment increased the biocompatibility of titanium implants by allowing them to induce more newly-formed bone quantity.
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