The morphogenesis of massive cerebral hemorrhagic lesions was studied in 6 experimental hypertensive rats. Hemorrhage due to rupture of arteries caused by hypertensive arterial lesions (plasmatic arterionecrosis) was found in the middle cerebral arteries in the subarachnoid space and immediately after their penetrating into the cerebral parenchyma. This primary hemorrhage induced, through circulatory disturbances, secondary bleedings of small vessels and veins, which were all combined to give rise to a massive hemorrhagic lesion. The hypertensive arterial lesions, which were the direct cause of the cerebral hemorrhage, were constituted by necrosis and disappearance of smooth muscle cells and blood plasma infiltration in the media, blood plasma infiltration, especially deposition of fibrin, having periodic cross striation of about 200 Å (fibrinoid degeneration) in the intima, and dissolution and disappearance of the internal elastic lamina.
The aim of this study was to analyze the relationship between cardiac function, vascular function, muscle strength index and the optimal load for exercise therapy, in order to establish a simple equation for estimating the optimal load for exercise therapy. [Participants and Methods] The subjects were 21 hemodialysis patients. The measurement items were left ventricular diastolic function, cardio ankle vascular index, muscle mass, grip strength and knee extension muscle strength. The optimal load weight ratio was defined as the value obtained by dividing the optimal load for exercise therapy by the body weight. [Results] Grip strength and knee extension muscle strength showed significant correlations with the optimal load weight ratio. Knee extension muscle strength was an independent determinant of the optimal load weight ratio, and the regression equation had moderate accuracy.[Conclusion] The results suggest that the optimal load for exercise therapy can be estimated from the knee extension muscle strength of hemodialysis patients.
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