Introduction: Obesity is considered a public health problem and it is associated with various musculoskeletal disorders, that haven´t been reviewed systematically. Therefore, the objective of this study was to describe the relationship between these changes in individuals with obesity. Methods: Lilacs, PubMed, Scielo, Scopus and Web of Science electronic databases were systematically reviewed until July 2018, conducted according to Cochrane guidelines for the development of meta-analysis. Eligibility criteria: inclusion (studies with humans; with a BMI greater than 30 Kg/m² or above the 85th and 95th percentile for children and adolescents; articles published in Portuguese, English, and Spanish; articles with validated evaluation methods); exclusion (duplicate, non-indexed articles; special populations; meeting summaries, editorials, letters to the editor and reviews). Results: Based on moderate evidence, knee postural changes in patients with obesity were found in two studies (n=158) (OR 14,26, IC 95% 4,98-40,80), I2 = 0% (p = 0,000), foot postural changes were found in 3 studies (n =338) (OR 3,20, IC 95% 2,08-4,94), I2=0% (p=0,000). Two studies were identified for arthritis (n=1331) (OR 3,38, IC 95% 0,72-1582), I2=38,95% (p=0,122). Pain was reported in the lower limb and the spine. Four studies were found for the former (n=1560) (OR 5,51 IC 95% 2,07-14,61), I2=81,02% (p=0,001), and three for the latter (n=499) (OR 9,78 IC 95% 2,59-36,93), I2=86,58% (p=0,000). Conclusion: Results show that obesity has a negative impact on musculoskeletal health, with results statistically significant for knee and foot postural changes, arthritis, and pain in the spine and lower limbs.
Angioedema Hereditário (AEH) é uma doença pouco conhecida por profissionais da saúde, portanto subdiagnosticada. O objetivo do estudo, foi analisar artigos referentes à temática abordada dos últimos 5 anos. AEH é uma doença genética rara e grave do sistema imunológico, de caráter autossômico dominante, causada pela deficiência de inibidor de C1 esterase (C1-INH). Classificada em 3 fenótipos: deficiência quantitativa do inibidor de C1-INH, disfunção de C1-INH e C1-INH normal. Mutações em diversos genes estão associadas ao fenótipo do AEH, pacientes com deficiência e disfunção da proteína C1-INH possuem mutações no gene SERPING1 e pacientes com C1-INH normal, podem apresentar mutações nos genes F12, angiopoietina (ANGPT1), plasminogênio (PLG) ou cininogênio (KNG1). Os sintomas do AEH são caracterizados por edemas recorrentes em várias partes do corpo, tanto em pele como órgãos internos. Para a elaboração deste estudo realizou-se uma revisão integrativa da literatura, os artigos foram pesquisados em três bases de dados eletrônicas, Google Scholar, PubMed e Scielo, utilizando os descritores “angioedema hereditário”, “mutações”, “bradicinina”, “C1-INH”, “SERPING1”, “plasminogênio”, “angiopoietina”, “F12” e “cininogênio”, conectados por operadores boleanos AND e OR. A pesquisa no banco de dados revelou um total de 874 artigos, após triagem, 32 artigos foram avaliados. Com a pesquisa tornou-se possível compreender não somente os mecanismos percursores que levam ao desenvolvimento da doença, mas também as mutações genéticas responsáveis pelas diversas formas de manifestações clínicas do AEH, corroborando a construção de conhecimento dos profissionais envolvidos no diagnóstico e tratamento da patologia.
Obesity is considered a public health problem and the review of the scientific literature allows the observation of several changes in the musculoskeletal system associated with this disease. The objective of this study is to describe the relationship between these changes in obese children and adults. This article is a scope review protocol, a study methodology based on the structure described by Arksey and O'Malley. The study protocol followed the recommendations from the Preferred Reporting Items for Systematic reviews and Meta-Analyzes extension for Scoping Reviews (PRISMA-ScR) Checklis. It will be conducted in five stages: a) elaboration of the research question; b) identification of relevant studies; c) selection of studies; d) data extraction; e) summary of the results. The study aims to correlate musculoskeletal disorders in obesity, in different stages of bone maturation, which are less studied, in order to provide scientific evidence to health care professionals involved in the multidisciplinary treatment of this chronic disease.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.