RESUMO
Objetivou-se nesse trabalho, estimar os parâmetros genéticos para características de crescimento em ovinos da raça Santa Inês através do Método da Máxima Verossimilhança Restrita (REML). Os componentes de (co)variâncias e os parâmetros genéticos foram estimados pelo
Amazonian (Trichechus inunguis) and West Indian (Trichechus manatus) manatees are
aquatic mammals vulnerable to extinction found in the Amazon basin and the
coastal western Atlantic. Toll-like receptors (TLR) play a key role in
recognizing pathogen-associated molecular patterns using leucine-rich repeats
(LRRs). We described the diversity of TLR4 and TLR8 genes in these two species
of manatee. Amazonian manatee showed seven SNPs in TLR4 and the eight in TLR8,
while West Indian manatee shared four and six of those SNPs, respectively. In
our analysis, TLR4 showed one non-conservative amino acid replacement
substitution in LRR7 and LRR8, on the other hand, TLR8 was less variable and
showed only conserved amino acid substitutions. Selection analysis showed that
only one TLR4 site was subjected to positive selection and none in TLR8. TLR4 in
manatees did not show any evidence of convergent evolution compared to species
of the cetacean lineage. Differences in TLR4 and TLR8 polymorphism may be
related to distinct selection by pathogens, population reduction of West Indian
manatees, or an expected consequence of population expansion in Amazonian
manatees. Future studies combining pathogen association and TLR polymorphism may
clarify possible roles of these genes and be used for conservation purposes of
manatee species.
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