La medición en el ámbito educativo del rendimiento académico de los estudiantes universitarios es considerada empírica y cuantitativa. De allí que el propósito principal de dichas evaluaciones consiste en el control de los sistemas educativos y la evaluación a partir de criterios objetivos (Long, Wendt, & Dunne, 2011). Este trabajo apunta a desarrollar un banco de ítems para el Test de Conocimiento General compuesto de 20 dominios específicos. Se presentan avances realizados en seis dominios (psicología, biología, historia, literatura, economía y leyes). La muestra estuvo compuesta por 6.794 estudiantes. Se evaluaron 1.526 ítems de distintos dominios. Se realizó un análisis factorial exploratorio no lineal, se obtuvieron los índices de dificultad y discriminación según la teoría clásica de los test y la teoría de respuesta al ítem; también se obtuvieron índices de fiabilidad. El 68% presenta dificultad moderada y 32% un índice de dificultad alto o bajo. Sobre los índices de confiabilidad en la mayoría de los dominios se obtuvieron valores satisfactorios superiores a ,70. Se concluye la necesidad de revisar los ítems que no cumplieron estos criterios y ampliar la muestra. Este instrumento permitirá reducir los errores de clasificación de los alumnos y medir el desempeño académico con una escala de intervalo.
Introduction: Visual manifestations are the most prominent non-painful features of migraine. During the last decades, visual area V3a has gathered attention of headache scientists because of its apparent implication on aura initiation, photophobia and cortical hyper-responsiveness related to visual motion perception. In this hypothesis-generating study, we performed an in silico analysis of gene expression in left V3a and the cerebral gyrus that harbours it (left superior occipital gyrus (lSOG)) searching for transcriptomic patterns that could be linked with migraine’s pathophysiology. Materials and methods: Neurotransmitter receptor gene expression levels in left V3a were extracted from validated brain mRNA expression models using a probabilistic volumetric mask of this region. The primary visual cortex and other sensory cortices (auditory, olfactory and somatosensory) were used as comparators. Genome-wide transcriptomic differences between the gyrus harbouring left V3a (lSOG) and the rest of the cerebral cortex were assessed using the Allen Brain Institute Human RNA micro array atlas/database. Results: Adrenergic receptor β1, dopaminergic receptor D3 and serotoninergic receptors 1B, 1F and 2A, which have been previously implicated in migraine’s pathophysiology and/or treatment, showed significantly higher expression levels on left V3a. Transcriptomic differences between the lSOG harbouring V3a and the rest of the cortex comprise genes whose products are involved in neuronal excitability (SLC17A6, KCNS1, KCNG1 and GABRQ), activation of multiple signal transduction pathways (MET) and cell metabolism (SPHKAP via its interaction with cAMP-dependent protein kinase). Conclusions: Focal gene expression analysis of V3a suggests some clues about its implication in migraine. Further studies are warranted.
In 2000, the United Nations placed Argentina among the countries with the oldest populations in Latin America. Ageing of the Argentinian population has progressed steadily over the decades, alongside a rise in the prevalence of dementia. In 2011, findings from the first Central Registry of Cognitive Pathologies were published, which showed that among all dementia types, Alzheimer’s disease, in any of its forms, was diagnosed in 70.5% of subjects. Regarding treatment, findings from the study also showed the considerable importance given to the specific treatment of behavioural and psychological symptoms of dementia. Non-pharmacological treatment is usually based on interventions directed to patients and families. In Argentina and worldwide, non-cognitive symptoms are the real core symptoms of dementia. However, difficulty in accessing care and treatment facilities due to long travel distances makes it challenging to implement traditional psycho-social interventions. In this context, computer-based cognitive interventions and telemedicine could offer a promising solution.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.