This article has an accompanying continuing medical education activity, also eligible for MOC credit, on page e18 (https://www. gastrojournal.org/cme/home). Learning Objective: Upon completion of this CME activity, successful learners will be able to explain the prevalence, predictors, and significance of hepatitis B surface antigen (HBsAg) seroclearance in adults with chronic hepatitis B virus (HBV) infection.

Both ETV and TDF showed potent antiviral activity against hepatitis B. Either ETV or TDF can be recommended as a treatment of choice for patients with chronic hepatitis B. Both drugs were safe and well tolerated.