A series of 6,7,8-substituted thiosemicarbazones (2a-j) of 2-chloro-3-formyl-quinoline derivatives were cyclized to the title compounds (3a-j) using acetic anhydride. The structures of the final compounds (3a-j) were confirmed by elemental and spectral (IR, 1 H NMR and MS) analysis. Some of the title compounds have shown promising anticancer and antitubercular activities.
A series of new 3-aryl-4-(6¢-aryl-imidazo[2,1-b][1,3,4]thiadiazol-2¢-yl-phenylsydnones (16 -27) were synthesized. The structures of the synthesized compounds were confirmed by the IR, 1 H NMR, and mass spectroscopy techniques and elemental analysis. All the newly synthesized compounds were evaluated for their anticancer activity against cervical cancer cell line (Hela) and antimicrobial activity, in particular, antitubercular activity against Mycobacterium tuberculosis (H 37 Rv).
Novel methylene bridged Mannich bases 2a-j were synthesized in good to excellent yields from the pyrazoline derivative 1 using various primary/secondary amines, 37 % formalin in presence of ionic liquids/TBAB as catalyst. The structures of the newly synthesized compounds were confirmed by IR, 1 H-and 13 C-NMR and GC-MS spectroscopy, as well as elemental analysis. The title compounds were screened for their anti-tubercular and antimicrobial activities. Some of the compounds exhibited very good anti-tubercular, antifungal and antibacterial activities.
Derivatives of 1,3-thiazolidin-2,4-dione appended to biphenyl ring viz., 7-9, 16-18 were prepared. The newly synthesized compounds were confirmed by IR, NMR ( 1 H and 13 C) MS and elemental analyses. Single crystal X-ray diffraction study was carried out for one of the final compounds 9.
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