Heterocyclic compounds with different heterocycle moieties, namely benzoxazinone, benzimidazole, quinazolinone, and benzofuranone heterocyclic rings, were synthesized, characterized, and evaluated for their anticancer activity against human hepatocellular carcinoma cell line (HepG2) using sulforhodamine B (SRB) and dimethylthiazol‐diphenyltetrazolium bromide (MTT) assays. Also, their cytotoxic activities were tested against human epithelioid carcinoma (Hela) cell line in comparison with normal cell, amniotic epithelial (WISH) cell line, as an in vitro toxicity estimation model. The results showed clearly that 2‐(2‐benzyl‐4‐oxoquinazolin‐3(4H)‐yl)acetohydrazide 4 is the most potent antioxidant and anticancer agents. Although, 3‐amino‐2‐benzylquinazolin‐4(3H)‐one 5 is less potent anticancer agent against Hela but it is more safe against normal cell (WISH).
Heterocyclic compounds with different heterocycle moieties, namely benzoxazinone, benzimidazole, quinazolinone, and benzofuranone heterocyclic rings, were synthesized, characterized and evaluated for their anticancer activities against Lung cancer cell line (A549) using Sulforhodamine B (SRB) assay. In vitro, a compound with benzoxazinone scaffold namely 2‐benzyl‐3,1‐benzoxazin‐4‐one was shown to have the best antiproliferative activity against Lung cancer cell line (A549) with IC50 values 53.9 μM in comparison with other heterocyclic rings. This compound showed an excellent cytotoxicity effect against the pancreatic cancer cell line (PANC‐1) with IC50 values 0.15 μM, while it has a slight effect on the hepatocellular carcinoma cell line (HepG2).
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