Background. Although Mycoplasma genitalium (MG) is an acknowledged cause of nongonococcal urethritis (NGU), access to diagnostic testing is limited. Syndromic management is common, yet little is known about natural history.Methods. Between August 2014 and April 2016, 13 heterosexual men aged ≥16 years with MG were identified within a cohort study of men with and without NGU attending an urban sexually transmitted diseases clinic. Men had 6-7 monthly visits. NGU was defined as ≥5 polymorphonuclear leukocytes per high-power field on urethral Gram stain plus either visible urethral discharge or urethral symptoms. Men with NGU received 1 g of azithromycin. Men with persistent NGU received moxifloxacin 400 mg for 14 days. First-void urine was retrospectively tested for MG using transcription-mediated amplification. Resistance-associated mutations were detected by polymerase chain reaction (PCR) and sequencing. Organism load was determined by quantitative PCR.Results. Sixty-two percent of MG-positive men had macrolide resistance-mediating mutations (MRMM) at enrollment; 31% had parC mutations (all outside the quinolone resistance-determining region). MG persisted after azithromycin in 7 men, 6 of whom had MRMM. The median duration of persistence in the absence of curative therapy was 143 days (range, 21-228). Five men experienced symptom resolution after azithromycin, but MG persisted for another 89-186 days before moxifloxacin. Organism load was somewhat lower in MRMM than wild-type infections (P = .16)Conclusions. The high prevalence of macrolide resistance and long duration of infection after symptom resolution highlights the need for diagnostic MG testing of men with NGU to direct therapy.
Objective To describe the work environment and COVID-19 mitigation measures for homeless shelter workers and assess occupational risk factors for COVID-19. Methods Between June 9-August 10, 2020, we conducted a self-administered survey among homeless shelter workers in Washington, Massachusetts, Utah, Maryland, and Georgia. We calculated frequencies for work environment, personal protective equipment use, and SARS-CoV-2 testing history. We used generalized linear models to produce unadjusted prevalence ratios (PR) to assess risk factors for SARS-CoV-2 infection. Results Of the 106 respondents, 43.4% reported frequent close contact with clients; 75% were worried about work-related SARS-CoV-2 infections; 15% reported testing positive. Close contact with clients was associated with testing positive for SARS-CoV-2 (PR 3.97, 95%CI 1.06, 14.93). Conclusions Homeless shelter workers may be at risk of being exposed to individuals with COVID-19 during the course of their work. Frequent close contact with clients was associated with SARS-CoV-2 infection. Protecting these critical essential workers by implementing mitigation measures and prioritizing for COVID-19 vaccination is imperative during the pandemic.
Among MSM/TGWSM, IAI may lead to transmission of yet-unidentified rectal micro-organisms that cause non-CT/non-MG NGU, in addition to transmission of known pathogens. Sites of urethral exposure appear less important for understanding NGU risk among MSW due to minimal variation in behaviour.
BackgroundWithin the mining industrial sector, workers in the mining and oil and gas extraction (OGE) industries have demonstrated disparities in chronic health status compared with the general working population. However, we know much less about miner and OGE worker health once retired. This study separately compares chronic illnesses in retired miners and OGE workers with all other retirees.MethodsNational Health Interview Survey (NHIS) public data were analyzed for the years 2007–2017 to estimate weighted unadjusted and adjusted prevalence of selected health conditions (cancer, cardiovascular disease, high cholesterol, diabetes, hypertension, respiratory conditions, health status, and hearing loss) in retirees. Three retired worker groups (miners, OGE, and other retirees) were defined using the respondents' longest‐held industry and occupation.ResultsHigher prevalence of a number of adverse health conditions was noted in miners and OGE workers when compared with all other retirees. A significantly higher adjusted prevalence of hypertension, hearing loss, functionally limiting lung problems, and fair or poor health was seen in miners over other retirees. Retired OGE workers demonstrated a significantly higher adjusted prevalence of both hearing loss and poor health status.ConclusionsMiners and OGE workers have higher morbidity during their working years, and this study demonstrates that poorer health appears to continue into retirement. These results suggest the need to expand occupational health and safety programs in the mining sector to improve the health of workers into retirement. Future studies that include more robust information on workplace exposures are needed to evaluate the long‐term health of retired workers.
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