During instances of capacity-demand imbalances, efficient planning and decision-making in air traffic flow management is contingent upon the "goodness" of the capacity distributions that estimate airport capacity over time. Airport capacities are subject to substantial uncertainty as they depend on stochastic weather conditions. In this paper, we develop models that take into consideration the stochastic nature of weather. The main objective of this paper is the development of probabilistic capacity forecasts. To assess the improvements that could be gained by using the capacity probabilistic forecasts, the capacity distributions developed in this paper are input into existing static, stochastic, ground holding models, which uses probabilistic capacity forecasts and determines the amount of ground delay to assign to incoming flights.

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The use of text mining and natural language processing can extend into the realm of knowledge acquisition and management for biomedical applications. In this paper, we describe how we implemented natural language processing and text mining techniques on the transcribed verbal descriptions from retinal experts of biomedical disease features. The feature-attribute pairs generated were then incorporated within a user interface for a collaborative ontology development tool. This tool, IDOCS, is being used in the biomedical domain to help retinal specialists reach a consensus on a common ontology for describing age-related macular degeneration (AMD). We compare the use of traditional text mining and natural language processing techniques with that of a retinal specialist's analysis and discuss how we might integrate these techniques for future biomedical ontology and user interface development.

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With cancer-related fatalities being the second leading cause of death in the USA, understanding the activity of effective chemotherapeutic agents is critical to addressing prostate and other cancers. Celecoxib, an FDA-approved drug for the treatment of colon tumors, has been used successfully as a lead compound in the development of antiproliferative agents. The ability of celecoxib to inhibit the development and progression of tumors has been connected to a number of mechanisms of actions that are both dependent on and independent of its cyclooxygenase-2 activity. A structure-based approach has been employed to develop a model that underscores the structural significance of celecoxib as an antiproliferative agent. By evaluating the structure activity of this library of molecules, we were able to create a QSAR model for predicting the antiproliferative activity of structurally similar molecules. The development of the model will be presented in this paper.

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March 2022Notices of the aMericaN MatheMatical society 417What do all of these people have in common? They are all mathematicians and Black women. These are the first 20 Black women to earn doctoral degrees in mathematics in the United States. 2 When you picture a mathematician, what image comes to mind? Chances are a vision of an African American woman is not your first image. We are all familiar with the stereotype of a mathematician.Since 1943 when the first Black woman, Dr. Euphemia Lofton Haynes, earned her doctorate, Black women continued to excel in the mathematical sciences, even if they did not earn a Ph.D. Case in point, the famous book, Hidden Figures, highlighted Katherine Johnson who served as a research mathematician at NASA 3 [Shetterly, 2016]. Did you know that she is considered the first African American to pursue graduate studies in mathematics; integrated West Virginia University; and pursued a master's degree in mathematics there, but did not earn the degree? 4 Yet she is one of the most famous mathematicians of our time given her groundbreaking research in the space race of the 1950s. She is also "the first female mathematician to be awarded the highest civilian honor in the U.S., the Presidential Medal of Freedom", which she was awarded by President Barack Obama in 2015 [Walker, 2017]. In addition, she and the other "computers" from NASA received a Congressional Medal of Honor in 2019. 5

1) To help the mathematical community understand the historical role of the AMS in racial discrimination; (2) To consider and recommend actions addressing the impact of such discrimination to the AMS Council and Board of Trustees.Given the nature of the work, the two co-chairs, after consultations with the AMS President, chose as members of the Task Force a group of racially diverse mathematicians at a variety of institutions, who had leadership experience (including several current or past members of the AMS Council) and who would be able to conduct interviews with the sensitivity required.The Task Force reviewed AMS archives, talked with AMS staff, interviewed mathematician colleagues, and sought direct input from the wider mathematics community. Our work was assisted by math historian Michael Barany and by AMS staff, especially Abbe Herzig and Andrea Williams. We produced the report Towards a Fully Inclusive Mathematics Profession, released in March 2021, that documented AMS policies, practices, and actions that have had discriminatory impact and described ways that the mathematics profession remains unwelcoming, especially to mathematicians of color. We also cataloged more recent efforts by many in the profession and the AMS to become more welcoming, and we made several recommendations for ways the AMS can improve how it fulfills the part of its mission that advocates for "the full participation of all individuals."Since the report's release, we've heard a number of reactions from mathematician colleagues through direct conversation as well as on social media. These reflect the diversity of viewpoints within the ranks of the Society. Some feel the report does not go far enough to castigate