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[1] To elucidate factors controlling the geometry of, and kinematics associated with, prominent upper-crustal structures in the Eastern Cordillera of NW Argentina, structural analyses of key areas were complemented by fault slip analysis, remote sensing and 3D representation of prominent faults. The analyses revealed that deformation during Tertiary to Quaternary times was accomplished mostly by prominent orogen-parallel reverse faults, the geometry of which was significantly influenced by Paleozoic and Cretaceous planar structures. Locally, this deformation was preceded by kilometer-scale doming of upper-crustal rocks. Analysis of 767 brittle faults at 67 stations in the studied areas indicates that local upper-crustal doming and orogen-parallel reverse faults formed chiefly under NW-SE and E-W shortening. Shortening directions inferred from fault slip data portray the kinematics of first-order faults and folds. More specifically, shortening directions are mostly uniform with respect to first-order structures.