Bacterial infections
pose a major threat to human health,
primarily because of the evolution of mutated strains that are resistant
to antibiotic treatment. As a viable alternative, several nanoparticles
have emerged as attractive antibacterial agents. Herein, we report
the development of iron sulfide (FeS) nanoparticles that show dual-modality
therapy: namely reactive oxygen species (ROS)-induced toxicity and
red-laser induced photothermal therapy. The aqueous synthesized nanoparticles
have been characterized based on their size, shape, crystallinity,
and magnetic and optical properties. These nanoparticles showed sustained
release of Fe2+ ions in an aqueous dispersion. They also
have a high absorption cross-section in the visible and near infra-red
regions and could be excited by a continuous wave diode laser of wavelength
635 nm leading to significant hyperthermia. Nanoparticle treatment,
followed by light irradiation, led to significant cell death in two
ghastly pathogenic bacterial strains. Stepwise enhancement of intrabacterial
ROS levels, as a result of nanoparticle treatment followed by light
activation, has been identified as the primary antibacterial mechanism.
Photoresponsive nanoparticles are capable of converting the light energy into heat and generate reactive oxygen species (ROS) to exert a variety of applications. In this study, we report a simple...
A highly efficient "Click with MCR" strategy for the three-step synthesis of two types of blue emitting chromene peptidomimetics is described. The peptidomimetics were synthesized via a copper-catalyzed [3[Formula: see text]2] azide-alkyne cycloaddition between chromene alkynes obtained from a three-component reaction and the peptide azides obtained from Ugi or Mannich type multicomponent reactions. The photophysical properties of the peptidomimetics are comparable with commercial fluorophores. Computational studies using drug property descriptors support the possibility of using these molecules for modulating difficult target classes having large, flat, and groove-shaped binding sites.
This review focuses on recent breakthroughs in the physicochemical approaches and biological approaches of metallic iron, iron sulfides, and iron oxide nanoparticles for a variety of applications. The range of kinds, topologies, and physicochemical features of nano-sized iron sulfides has piqued researchers' curiosity. Furthermore, this study examines the medicinal, environmental, and technical uses of biogenically synthesized NPs, as well as the hurdles that must be overcome in order to optimize the environmentally friendly production of these critical nanoparticles. FeS NPs have a good effect on biological activity due to their ease of production, magnetic properties, biocompatibility, and biodegradability. Also canvased are the FeS NPs nanoparticle-specific biomedical applications in cancer treatments. The goal of this review is to discuss the synthesis, characteristics, and uses of nano sized FeS NPs in biomedical domains, revealing that they have significant promise for enhancing human health and excellence of life.
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