The mechanical properties of extracellular matrix (ECM) and connective tissues is largely dependent on the collagen and elastin structure. Lysyl oxidase (LOX) plays a critical role in the formation and repair of the ECM by oxidizing lysine residues in elastin and collagen, thereby initiating the formation of covalent cross linkages which stabilize these fibrous proteins. Due to its multiple functions both extracellularly and intracellularly, lysyl oxidase is involved in several processes in the tumorigenic pathway, in many different cancer types and stages. Alteration in LOX activity is implicated in many diseases and disorders including inflammation and inflammatory diseases, fibrosis of distinct organs and fibrotic disorders, cancer promotion and progression. There are only sparse reports of mutations or epigenetic alterations in the LOX gene. This review provides the recent clinical developments in the molecular mechanisms and pathologic process, pointing out LOX as a potential therapeutic target in translational medicine.
There is accumulating evidence showing relationship between trace elements and Diabetes mellitus (DM). This study evaluated the role of magnesium, Zinc and other indices of peroxidative status ie MDA, Vitamin C and Vitamin E in pathogenesis of Retinopathy in type 2 diabetes. Seventy two type 2 diabetes cases were enrolled in the study, of which 42 were with retinopathy and 30 without. Patients with nephropathy were excluded. Forty age-and sexmatched subjects were served as health controls. The results showed that the mean values of Mg and Zn were significantly lower reduced in diabetes more so in diabetic retinopathy cases as compared to control subjects (p<0.05). Lipid peroxidation marker MDA was a significantly higher in both the diabetes groups whereas serum Vitamin C and vitamin E levels were significantly low (p<0.05) as compared to controls. Our correlation study revealed that MDA was negatively associated with serum Mg (r=-0.73, p<0.01) as well as serum Zn (r= -0.82, p<0.01), pointing towards the role of these trace elements in retarding the oxidative process prevailing in diabetic retinopathy.
BACKGROUNDIn this new era of increased pollution and dusty atmosphere, there is high risk of eyes getting exposed to allergens and its manifestation in form of vernal keratoconjunctivitis. It is still one of the iceberg phenomenon diseases which needs early diagnosis and intervention. Hence this study was conducted with an objective to identify the clinico demographic profile of this condition in Central Odisha. MATERIALS AND METHODSA hospital based prospective study of 180 patients selected from Ophthalmology OPD, SCB MCH, Cuttack from April 2016 to March 2018 to study their epidemiology, clinical parameters (types, symptoms) and severity of this condition. RESULTSVernal keratoconjunctivitis was found to affect more young males below 16 years (72%). Itching was the commonest presentation. Palpebral form was the predominant variety of all the three. CONCLUSIONVernal keratoconjunctivitis affects many school going children and in summer season with varied clinical symptoms and signs. So, this condition still needs thorough evaluation and meticulous approach for early diagnosis and reduced morbidity.
Background: Dry eye condition has multi-factorial origin and most of the times missed or left untreated leading to resistance in its treatment modalities. Various studies had been conducted with conflicting outcomes. Dry eyes condition being more prevalent in Odisha, there is very limited published data on its management. Hence this study was conducted to evaluate the efficacy and outcome of medical and surgical management of dry eye cases due to different aetiologies.Methods: Patients were selected from those who attended ophthalmology, Skinand VD, O and G and Paediatrics OPD. Their tear film parameters like Tear film breakup time, tear meniscus height, Schirmer test, Rose Bengal stain were assessed at baseline level. Thereafter they were put on medical therapy for 6 weeks followed by appropriate surgical intervention like amniotic membrane graft, punctual occlusion, use of Symblepharon shell in resistant cases -which again was reviewed by analysis of tear film parameters.Results: Majority of patients (75% approx.) responded well to medical therapy. non responders were due to Steven Johnson syndrome, Vitamin A deficiency, KCS and systemic association. These patients underwent surgical management with follow up after 6 weeks. After 6 weeks of surgical therapy 80% cases showed improvement, while few cases due to SJS showed poor response.Conclusions: The medical modality of treatment was found to be the primary approach with better efficacy in majority of dry eye cases predominantly in mild to moderate severity. Surgical interventions proved more efficacious in severe degree of presentation.
BACKGROUND In this modern age of high dependence on electronic gadgets, pollution, there is an increasing tendency of eyes getting affected with Dry Eyes Syndrome. This is one of the common yet under-diagnosed eye problems in Odisha. Hence, this study was conducted with an objective to identify the clinico demographic profile and incidence of dry eyes in eastern Odisha. MATERIALS AND METHODS The patients were selected from Ophthalmology, Skin & VD, OBG, Paediatrics OPDs. Detailed history was taken; local and systemic examination were done along with specific emphasis on tear film characteristics. The parameters were assessed for different aetiologies of dry eye syndromes and compared to know the distribution of this condition. RESULTS Dry eyes were found more commonly in laborers and in patients suffering from Keratoconjunctivitis Sicca and vitamin A deficiency. There is a decrease in values of blink rate, tear film breakup time, tear meniscus height, Schirmer's Test readings. CONCLUSION Dry eyes affect all the age groups depending upon the aetiology being involved. So, this condition still needs thorough evaluation and meticulous approach for proper diagnosis and reduced morbidity.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.