We proposed and fabricated multiscale transparent arteriole and capillary vessel models with circular cross sections of 10-500 m using photolithography. The circularities of the fabricated 10, 50, and 500 m diameter microchannels were 84.0%, 61.5%, and 82.3%, respectively. Next, we connected these different models to realize a circulation type blood vessel model simulating arteriole networks. We proposed a novel connection method using an intermediate connector made of wax, which we used to connect these models to make a circulation model. In flow experiments, the fabricated models showed no leakage and circulation models with seamless connections were achieved.
from the scaffold, seeding cells in the scaffold uniformly and In this study, we succeeded in fine construction of the in a high density, and supply of gas and nourishment to the PLCL (poly-L-lactide-co-c-caprolactone) scaffold with cell are demanded [ 1I]. For regeneration of complicated micrometer range resolution using photolithography.organs with fine blood vessels, fabrication of the scaffold
To reproduce blood vessel, we proposed new process for fabricating biodegradable scaffold by powder sintering process.In this process, model for molding scaffold was materialized by rapid prototyping. Biodegradable polymer powder and porogen were dusted to model and heated. So, arbitrary shape scaffold would be fabricated. Also, porosity that influences compliance of blood vessel scaffold would be adjusted by changing ratio of the polymer powder and porogen. We studied fabrication condition of blood vessel scaffold by measuring porosity and Young's modulus when the ratio of the polymer powder and porogen was adjusted. Also, HUVECs were cultured on the scaffold, and the scaffold's biocompatibility was confirmed.
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