The vapor pressures and the aqueous solubilities of 411 compounds with a large structural diversity were investigated using a quantitative structure-property relationship (QSPR) approach. A five-descriptor equation with the squared correlation coefficient (R 2 ) of 0.949 for vapor pressure and a six-descriptor equation with R 2 of 0.879 for aqueous solubility were obtained. All descriptors were derived solely from the chemical structure of the compounds. The QSPR correlation equations for vapor pressure and aqueous solubility allow the reliable prediction of water-air partition coefficients.
A comparative study of metal-free air-operated polypyrrole and PEDOT based trilayer actuators is presented. Actuators made of both pure and combined conducting polymers are considered. Trilayer bending actuators, synthesized in similar conditions, are characterized in terms of the structure, electrochemical and electro-chemo-mechanical properties. The characterization was carried out using two popular electrolytes: LiTFSI in propylene carbonate and a room-temperature ionic liquid EMIm TFSI. The results reveal that structure and actuation properties of the synthesized actuators depend on both the polymer chosen for the chemically synthesized electrode layer as well as the electrochemically synthesized working layer.
Additive
manufacturing allows three-dimensional printing of polymeric
materials together with cells, creating living materials for applications
in biomedical research and biotechnology. However, an understanding
of the cellular phenotype within living materials is lacking, which
is a key limitation for their wider application. Herein, we present
an approach to characterize the cellular phenotype within living materials.
We immobilized the budding yeast
Saccharomyces cerevisiae
in three different photo-cross-linkable triblock polymeric hydrogels
containing F127-bis-urethane methacrylate, F127-dimethacrylate, or
poly(alkyl glycidyl ether)-dimethacrylate. Using optical and scanning
electron microscopy, we showed that hydrogels based on these polymers
were stable under physiological conditions, but yeast colonies showed
differences in the interaction within the living materials. We found
that the physical confinement, imparted by compositional and structural
properties of the hydrogels, impacted the cellular phenotype by reducing
the size of cells in living materials compared with suspension cells.
These properties also contributed to the differences in immobilization
patterns, growth of colonies, and colony coatings. We observed that
a composition-dependent degradation of polymers was likely possible
by cells residing in the living materials. In conclusion, our investigation
highlights the need for a holistic understanding of the cellular response
within hydrogels to facilitate the synthesis of application-specific
polymers and the design of advanced living materials in the future.
Principal component analysis (PCA) has been carried out with 40 solvent scales as variables, each having 40 data points for 40 solvents as objects. The first three components account for 74% of the total variance. For 36 of the scales, an average of 88% of the variance is described by the first three principal components. The solvents and the solvent scales are grouped according to the scores and loadings obtained from PCA treatment. This allows comparison of both solvent scales and characterization of individual solvents.
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