Entropy and complexity of the electroencephalogram (EEG) have recently been proposed as measures of depth of anesthesia and sedation. Using surrogate data of predefined spectrum and probability distribution we show that the various algorithms used for the calculation of entropy and complexity actually measure different properties of the signal. The tested methods, Shannon entropy (ShEn), spectral entropy, approximate entropy (ApEn), Lempel-Ziv complexity (LZC), and Higuchi fractal dimension (HFD) are then applied to the EEG signal recorded during sedation in the intensive care unit (ICU). It is shown that the applied measures behave in a different manner when compared to clinical depth of sedation score--the Ramsay score. ShEn tends to increase while the other tested measures decrease with deepening sedation. ApEn, LZC, and HFD are highly sensitive to the presence of high-frequency components in the EEG signal.

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Cutting off high frequencies from the electroencephalogram and increased remifentanil concentration deteriorate the performance of the electroencephalogram-based entropy/complexity measures as indicators of the depth of propofol sedation.

Because Cortical State responds principally to variations in CePROP, it is a potential measure of hypnosis, whereas the dependence of Cortical Input on effect-site remifentanil concentration suggests that it may be useful as a measure of analgesic efficacy and the nociceptive-antinociceptive balance.

Neural mass model-based tracking of brain states from electroencephalographic signals holds the promise of simultaneously tracking brain states while inferring underlying physiological changes in various neuroscientific and clinical applications. Here, neural mass model-based tracking of brain states using the unscented Kalman filter applied to estimate parameters of the Jansen-Rit cortical population model is evaluated through the application of propofol-based anesthetic state monitoring. In particular, 15 subjects underwent propofol anesthesia induction from awake to anesthetised while behavioural responsiveness was monitored and frontal electroencephalographic signals were recorded.The unscented Kalman filter Jansen-Rit model approach applied to frontal electroencephalography achieved reasonable testing performance for classification of the anesthetic brain state (sensitivity: 0.51; chance sensitivity: 0.17; nearest neighbor sensitivity 0.75) when compared to approaches based on linear (autoregressive moving average) modelling (sensitivity 0.58; nearest neighbor sensitivity: 0.91) and a high performing standard depth of anesthesia monitoring measure, Higuchi Fractal Dimension (sensitivity: 0.50; nearest neighbor sensitivity: 0.88). Moreover, it was found that the unscented Kalman filter based parameter estimates of the inhibitory postsynaptic potential amplitude varied in the physiologically expected direction with increases in propofol concentration, while the estimates of the inhibitory postsynaptic potential rate constant did not. These results combined with analysis of monotonicity of parameter estimates, error analysis of parameter estimates, and observability analysis of the Jansen-Rit model, along with considerations of extensions of the Jansen-Rit model, suggests that the Jansen-Rit model combined with unscented Kalman filtering provides a valuable benckmark for future real-time brain state tracking studies. This is especially true for studies of more complex, but still computationally efficient, neural models of anesthesia that can more accurately track the anesthetic brain state, while simultaneously inferring underlying physiological changes that can potentially provide useful clinical information.

Unmanned aerial vehicle (UAV) based remote sensing is gaining momentum worldwide in a variety of agricultural and environmental monitoring and modelling applications. At the same time, the increasing availability of yield monitoring devices in harvesters enables input-target mapping of in-season RGB and crop yield data in a resolution otherwise unattainable by openly availabe satellite sensor systems. Using time series UAV RGB and weather data collected from nine crop fields in Pori, Finland, we evaluated the feasibility of spatio-temporal deep learning architectures in crop yield time series modelling and prediction with RGB time series data. Using Convolutional Neural Networks (CNN) and Long-Short Term Memory (LSTM) networks as spatial and temporal base architectures, we developed and trained CNN-LSTM, convolutional LSTM and 3D-CNN architectures with full 15 week image frame sequences from the whole growing season of 2018. The best performing architecture, the 3D-CNN, was then evaluated with several shorter frame sequence configurations from the beginning of the season. With 3D-CNN, we were able to achieve 218.9 kg/ha mean absolute error (MAE) and 5.51% mean absolute percentage error (MAPE) performance with full length sequences. The best shorter length sequence performance with the same model was 292.8 kg/ha MAE and 7.17% MAPE with four weekly frames from the beginning of the season.

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