Thyroid dysfunctions are common endocrine problems. They are often misdiagnosed, misunderstood, and frequently overlooked. These disorders affect almost every aspect of health. Most of them remain undetected because the clinical assessment alone lacks both sensitivity and specificity. As it is not sufficient enough we require the biochemical tests to confirm the diagnosis. As a consequence there is still great interest in new biomarkers that complement existing diagnostic tools. Osteopontin, a glycoprotein that can be detected in plasma, was found to be upregulated in several patients with hyperthyroidism and downregulated in hypothyroid patients so it may represent a new biomarker. 100 patients with thyroid dysfunctions (50 hyperthyroid, 50 hypothyroid) and 100 normal subjects were included in the study. Osteopontin and other clinical parameters for diagnosis of thyroid disorders were measured. Osteopontin is positively correlated with T3 and T4 (r = 0.62 and r = 0.75 respectively) while it is negatively correlated with thyroid stimulating hormone (r = −0.52) showing a significant correlation (p-value <0.001). Our findings suggest that osteopontin might be useful as a novel prognostic biomarker in patients with impaired thyroid function.
Objective: To determine the affect of autonomy on clinical chemicaltesting in pathology department Quaid-i-Azam Medical College and to assess the change in the attitudes oflaboratorians and physicians Study design: Retrospective and comparative. Duration of study: 1-11-93 to 01-11-03Materials and Methods: A retrospective study was carried out from 1-11-93 to 01-11 03 in which records from 1-11-93to 1-11-03 were collected and evaluated .Separate record of each month’s revenue from clinical chemistry section wascalculated. In order to determine what changes have been brought about after autonomy a universal questionnairewas used to assess the attitudes of physicians and surgeons of hospital inquiring whether they noticed anyimprovement in the efficiency of clinical chemical test results after autonomy. 620 doctors were interviewed throughstructured questionnaire. The questionnaire was designed to assess the knowledge , attitude and practices of doctorstowards autonomy. In order to determine that who is the most beneficent of autonomy ,different records werecollected. and discussions were made with consultants. Results: Autonomy brought about a healthy change in the staffof clinical chemical section. Quality control has improved the morale of lab staff since technical deviations are morereadily identified and corrected within the lab, gross errors are rarely found by the clinicians and so their respect forand confidence in the lab has strengthened Replenishment of chemicals/reagents are timely made. The number ofavailable test has significantly increased which in turn has significantly raised the revenue generated since autonomy is awarded. Pilferage of chemicals has been stopped. Turn around time has been decreased. Clinical Chemical sectionparticipates in External Quality Assessment Scheme, NEQAPP (National External Quality Assessment ProgramPakistan),which is an essential part of the routine of a well –run lab. Patient is the most beneficent since autonomy isawarded to QMC/BVH, BWP. Conclusions: A significant improvement in the efficiency of the analytical performancehas strengthened the faith of laboratorians and physicians in the test results after autonomy
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.