The overall survival rate for all cancers has increased over the past decades. 1 This has, in turn, substantially increased the amount of effort required to address the side effects of cancer therapies. Healthcare professionals should proactively adopt strategies to improve the quality of life of cancer survivors and maximize their reintegration into the community and daily work routine after recovery from cancer. A significant challenge that might decelerate or prevent the social rehabilitation of cancer survivors is cancer-induced cognitive impairment, also colloquially known as "chemobrain" or "chemofog." It has been reported that 10-40% of all cancer patients suffer from cancerinduced cognitive impairment. 2 Most importantly, several cancer patients with this complication eventually quit or change their professions; around 30% fail in their previous positions within two years after cancer therapy. 3,4 Cancer-induced cognitive impairment can be associated with the disease and its treatments such as chemotherapy, radiotherapy, hormone therapy, and novel anticancer treatments. [5][6][7][8][9] Existing evidence originating from both preclinical animal models and human trials has demonstrated that chemotherapy regimens, especially those containing anti-metabolic agents such as methotrexate, may cause long-lasting cognitive impairment. 5,10 Chemotherapy-related cognitive impairment (CRCI) encompasses a range of mild neurological impedi-
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