Psoriasis patients could be suggested as a group with an increased atherosclerotic risk especially in older ages with longer duration of Ps. The carotid IMT, ID and AWMI can identify patients with subclinical atherosclerosis who need special follow up to reduce cardiovascular morbidity and mortality.
Background: Plasma gel is a gelatinous substance made of proteins that have been gelled together and includes fibrin, which gives the formula more firmness and resistance than regular platelet-rich plasma. The aim of this work was to evaluate the safety and efficacy of autologous plasma gel injection in treatment of tear trough deformity.
Methods: This study was carried out on 10 female patients presented with tear trough deformity without prior cosmetic therapy or performed any facial surgery. Female patients were received two sessions of autologous plasma gel injection at 2- week interval.
Results: There was statistically significant improvement (decrease) in Tear Trough Rating Scale after intervention compared to before intervention (P=0.004). Regarding patient satisfaction after treatment, all patients showed various degree of satisfaction as follows: there was any patient very satisfied, 2 patients (20%) satisfied, 4 patients (40%) neutral, 3 patients (30%) dissatisfied, and 1 patient (10%) very dissatisfied.
Conclusions: The present study showed that plasma gel was safe and effective in the treatment of Tear Trough Deformity. Plasma gel give significantly better outcome as regard global improvement, complications and patient satisfaction.
Background: Psoriasis is a common inflammatory skin disorder. The typical cutaneous lesions are papules and plaques covered with silvery scales distributed mainly on extensor aspects of extremities. The course and progression of the disease are unpredictable and vary in each patient. YKL-40 is a new inflammatory biomarker which may be involved the pathogenesis of the disease.
Objective: The aim of this study was to study YKL-40 expression in patients with psoriasis to evaluate its possible role in the pathogenesis of psoriasis.
Patients and Methods: This study included 30 patients with chronic plaque psoriasis and 10 healthy individuals of matched age and sex served as a control group. Punch biopsies of four mm were taken from the skin of psoriatic patients as well as from corresponding sites of control subjects. All specimens were examined by both hematoxylin and eosin stain and anti-YKL-40 stain.
Results: The intensity of YKL-40 expression was upregulated in both epidermis and dermis of psoriatic skin in comparison with normal skin of control subjects. YKL-40 expression in psoriatic skin showed significant positive correlation with Psoriasis Area and Severity Index (PASI) score.
Conclusion: YKL-40 involved in the pathogenesis of psoriasis manifested by its up-regulation in skin of psoriatic patients group in comparison to control group.
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