In previous studies we have observed that several polyphenolic molecules can inhibit growth and induce the synthesis of differentiation markers in colon cancer cells. In the present work we have sought to determine if similar activity can be observed with methanolic and ethanolic extracts from okra and drumstick. In okra, phenolic molecules and antioxidant activity were associated primarily with the seeds, whereas in drumstick the seeds had lower concentrations of phenolics and antioxidant activity than skin, pulp and seed coat. In studies with okra extracts we have concentrated on the effects of seed extracts because they were generally most inhibitory for cell proliferation as judged by protein yield, thymidine incorporation into DNA and tetrazolium salt reduction. With extracts from drumstick the greatest inhibition of growth was generally with seed coat extracts but anomalous results were obtained in assays of tetrazolium salt reduction. Inhibition was greater at low concentrations but at high concentrations the apparent effect was reversed. Studies in the absence of cells showed that a component of the drumstick seed-coat extract reacted directly to reduce the tetrazolium salt. Comparison with other parts of the drumstick indicated that this reduction was much greater with the seed coat extract. Small effects on colon cancer cell differentiation have been seen with extracts of okra seed and with pulp and seed extract from drumstick as judged by induction of alkaline phosphatase activity. In the case of okra seed extracts this effect was additive with the action of butyrate. Okra and drumstick have had a role in traditional medicine and the present data are encouraging for further studies on potential cancer chemopreventive action. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5439. doi:1538-7445.AM2012-5439
Introduction:The most common pediatric fractures involve the upper extremity. But there is limited study on racial disparity in diagnostic radiography for pediatric fractures. The literature has described the diagnostic accuracy of alternative diagnostic modalities with promising evidence of its ability to mitigate health inequity in primary care. Our objective was to understand if racial disparity exists in radiography for pediatric fractures.Methods: In this four-year retrospective cohort study, we analyzed rates of radiographic imaging and abnormal radiograph detection in 4280 pediatric patients (ages 3-18 years) who presented with chief complaints of arm or wrist pain and trauma-related International Classification of Diseases 10th Revision (ICD-10) codes. We compared White children to all other races and stratified by emergency departments (ED) vs all other primary care ambulatory service lines.Results: Non-White patients had lower imaging rate differences and lower odds receiving imaging in both ambulatory settings (0.65915, P = 0.0162; -5.4%, P = 0.0143) and in EDs (0.7732, P = 0.0369; -4.7%, P = 0.0368). Additionally, non-Whites in the ED had lower rates and lower odds of abnormal radiographs (-7.3%,
Both gout and pseudogout are crystal-induced arthropathies. Here, we report a case of acute calcium pyrophosphate dihydrate (CPPD) arthritis associated with type 1 myocardial infarction (MI). An 83-year-old female presented to our emergency department with generalized weakness and bilateral lower extremity edema. Her left foot was noted to be more inflamed compared to the right, with cardinal signs of pain, swelling, erythema, and warmth. A presumptive diagnosis of cellulitis was made, and antibiotics were initiated. Further investigations revealed elevated troponins with new-onset bundle branch block, ST, and Twave changes on electrocardiogram, indicating a type 1 MI. After a review of the patient's history, imaging of the extremity, elevated inflammatory markers, and the typical distribution and pattern of inflammation, the diagnosis was changed to pseudogout. Steroids and colchicine were initiated, providing instant relief. This case highlights a possible association between cardiovascular disease and pseudogout, emphasizing the need for further studies regarding this relationship. Despite being rare, physicians should be made aware of this relationship, especially in patients with a history of CPPD arthritis presenting with type 1 MI.
Both pseudogout and cellulitis are diseases that may mimic one another in clinical practice. We discuss two cases of acute calcium pyrophosphate dihydrate (CPPD) arthritis mistaken for cellulitis in the emergency department. Both patients experienced significant improvement after management was changed to treat CPPD. These cases highlight how it is essential for physicians to consider CPPD as a differential diagnosis for a patient that is presenting with signs of inflammation in any joint.
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