Two isozymes of heme oxygenase (HO), HO-1 or HSP32 and the constitutive form HO-2, have been characterized to date. We report the discovery of a third protein species and refer to it as HO-3. HO-3 is the product of a single transcript of ~2 . 4 kb and can encode a protein of =33 kDa. The HO-3 transcript is found in the spleen, liver, thymus, prostate, heart, kidney, brain and testis and is the product of a singlecopy gene. The predicted amino acid structure of HO-3 differs from both HO-1 (HSP32) and HO-2 but is closely related to HO-2 (~9 0 % ) .Escherichia coli expressed and purified HO-3 protein does not cross react with polyclonal antibodies to either rat HO-1 or HO-2, is a poor heme catalyst, and displays hemoprotein spectral characteristics. The predicted protein has two heme regulatory motifs that may be involved in heme binding. These motifs and the hemoprotein nature of HO-3 suggest a potential regulatory role for the protein in cellular processes which are heme-dependent.

The heme oxygenase (HO) system degrades heme to biliverdin and CO and releases chelated iron.

We discuss an approach to obtaining black hole quasinormal modes (QNMs) using the asymptotic iteration method (AIM), initially developed to solve second order ordinary differential equations.We introduce the standard version of this method and present an improvement more suitable for numerical implementation. We demonstrate that the AIM can be used to find radial QNMs for Schwarzschild, Reissner-Nordström (RN) and Kerr black holes in a unified way. An advantage of the AIM over the standard continued fraction method (CFM) is that for differential equations with more than three regular singular points Gaussian eliminations are not required. However, the convergence of the AIM depends on the location of the radial or angular position, choosing the best such position in general remains an open problem. This review presents for the first time the spin 0, 1/2 & 2 QNMs of a Kerr black hole and the gravitational and electromagnetic QNMs of the RN black hole calculated via the AIM, and confirms results previously obtained using the CFM.We also presents some new results comparing the AIM to the WKB method. Finally we emphasize that the AIM is well suited to higher dimensional generalizations and we give an example of doubly rotating black holes.

The research field of man-made nano/micromotors is growing significantly at the level of new materials and fabrication, as well as numerous exciting demonstrations, ranging from Visible light-driven nano/micromotors are promising candidates for biomedical and environmental applications. This study demonstrates blue light-driven Ag/AgCl-based spherical Janus micromotors, which couple plasmonic light absorption with the photochemical decomposition of AgCl. These micromotors reveal high motility in pure water, i.e., mean squared displacements (MSD) reaching 800 µm 2 within 8 s, which is 100× higher compared to previous visible light-driven Janus micromotors and 7× higher than reported ultraviolet (UV) light-driven AgCl micromotors. In addition to providing design rules to realize efficient Janus micromotors, the complex dynamics revealed by individual and assemblies of Janus motors is investigated experimentally and in simulations. The effect of suppressed rotational diffusion is focused on, compared to UV light-driven AgCl micromotors, as a reason for this remarkable increase of the MSD. Moreover, this study demonstrates the potential of using visible light-driven plasmonic Ag/AgCl-based Janus micromotors in human saliva, phosphate-buffered saline solution, the most common isotonic buffer that mimics the environment of human body fluids, and Rhodamine B solution, which is a typical polluted dye for demonstrations of photocatalytic environmental remediation. This new knowledge is useful for designing visible light driven nano/micromotors based on the surface plasmon resonance effect and their applications in assays relevant for biomedical and ecological sciences. Janus Micromotors